2-氯-6-甲基吡啶-4-羧酸合成路线 （共 24 条）
参考文献
Dow AgroSciences LLC
Patent: US5968875 A1, 1999 ;
反应条件
in diethyl ether; ethanol
参考文献
MERCK FROSST CANADA LTD.
Patent: WO2008/46226 A1, 2008 ;
Location in patent: Page/Page column 38; 39 ;
WO 2008/046226 A1
反应条件
1,1'-carbonyldiimidazole; hydrazine in tetrahydrofuran T=20°C;
参考文献
LUPIN LIMITED; IRLAPATI, Nageswara, Rao; SHAIKH, Zubair, Abdul Wajid; KARCHE, Vijay, Pandurang; DESHMUKH, Gokul, Keruji; SINHA, Neelima; PALLE, Venkata, P.; KAMBOJ, Rajender, Kumar
Patent: WO2013/164769 A1, 2013 ;
反应条件
1.1: sulfuric acid / 24 h / 70 °C 1.2: pH 8 2.1: sodium t-butanolate / palladium diacetate; 9,9-dimethyl-4,5-bis(diphenyl-phosphino)xanthene / tetrahydrofuran / 42 h / 110 °C / Inert atmosphere 2.2: 18 h / 100 °C View Scheme
反应条件
1: With potassium tert-butylate T=90°C; 168 h; 2: With hydrogenchloride in water
参考文献
Actelion Pharmaceuticals Ltd.
Patent: US2010/63108 A1, 2010 ;
Location in patent: Page/Page column 18 ;
US 20100063108 A1
反应条件
1: sodium sulfide; ammonia; copper(II) sulfate / 155 °C 2: methanol / 50 °C View Scheme
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH
Patent: US2012/264729 A1, 2012 ;
反应条件
1: With borane-THF in tetrahydrofuran T=0 - 20°C; 49 h; 2: With hydrogenchloride in tetrahydrofuran; water T=0°C; 0.5 h; 3: With sodium hydroxide in tetrahydrofuran; water
参考文献
Guo, Hongyan; Kim, Choung U.; Kim, Hae Soo; Lee, Chong-Kyo; Lee, Ill Young; Mitchell, Michael L.; Son, Jong Chan; Xu, Lianhong
Patent: US2008/70920 A1, 2008 ;
Location in patent: Page/Page column 37 ;
参考文献
Bilodeau, Mark T.; Hartman, George D.
Patent: US2003/100567 A1, 2003 ;
反应条件
hydrogen; triethylamine in ethanol T=20°C;
参考文献
ASTRA ZENECA AB; NPS PHARMACEUTICALS, INC.
Patent: WO2004/14881 A2, 2004 ;
Location in patent: Page 99 ;
WO 2004/014881 A2
反应条件
durch Destillation mit Kalk;
参考文献
Aston; Collie
Journal of the Chemical Society, 1897 , vol. 71, p. 653,655
