2-氯-6-甲基吡啶-4-羧酸合成路线 （共 24 条）
反应条件
thionyl chloride; N,N-dimethyl-formamide in toluene 4 h; Heating / reflux;
参考文献
NEUROGEN CORPORATION
Patent: WO2008/70014 A2, 2008 ;
Location in patent: Page/Page column 62 ;
WO 2008/070014 A2
反应条件
sodium sulfide; ammonia; copper(II) sulfate in water
T=155°C; Autoclave;
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH
Patent: US2012/264729 A1, 2012 ;
Location in patent: Page/Page column 9 ;
反应条件
1: triethylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 2 h / 60 °C
2: tetrahydrofuran / 0 °C
View Scheme
参考文献
RAQUALIA PHARMA INC.; YAMAGISHI, Tatsuya; KAWAMURA, Kiyoshi; MORITA, Mikio
Patent: WO2013/161308 A1, 2013 ;
反应条件
1.1: 92 percent / aq. HCl / 6 h / Heating
2.1: n-BuLi / hexane; tetrahydrofuran / 0.25 h / -78 °C
2.2: ZnCl2 / hexane; tetrahydrofuran / 0.5 h / 20 °C
2.3: 84 percent / DIBAH / PdCl2-(PPh3)2 / hexane; tetrahydrofuran / 1.5 h / Heating
View Scheme
参考文献
Havas, Fabien; Danel, Mathieu; Galaup, Chantal; Tisnes, Pierre; Picard, Claude
Tetrahedron Letters, 2007 , vol. 48, # 6 p. 999 - 1002
