5-(3-吡啶基)-1,3,4-噻二唑-2-胺合成路线 （共 6 条）
反应条件
1: With methanesulfonic acid in toluene 16 h; Inert atmosphereReflux; 2: With ammonium hydroxide in water Inert atmosphere;
参考文献
Meissner, Anja; Boshoff, Helena I.; Vasan, Mahalakshmi; Duckworth, Benjamin P.; Barry III, Clifton E.; Aldrich, Courtney C.
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 21 p. 6385 - 6397
反应条件
iron(III) chloride in ethanol 2 h; Heating;
参考文献
Turner, Stephen; Myers, Malcolm; Gadie, Brian; Nelson, Anthony J.; Pape, Robin; et al.
Journal of Medicinal Chemistry, 1988 , vol. 31, # 5 p. 902 - 906
反应条件
1.1: tetrahydrofuran / 168 h / 23 °C / |Inert atmosphere 2.1: methanesulfonic acid / toluene / 16 h / |Inert atmosphere; |Reflux 2.2: |Inert atmosphere View Scheme
参考文献
Meissner, Anja; Boshoff, Helena I.; Vasan, Mahalakshmi; Duckworth, Benjamin P.; Barry III, Clifton E.; Aldrich, Courtney C.
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 21 p. 6385 - 6397
参考文献
Hemmerich et al.
Helvetica Chimica Acta, 1958 , vol. 41, p. 2058,2065
反应条件
hydrogenchloride; sodium nitrite
Erwaermen nach Zusatz weiterer wss. HCl;
参考文献
Turner, Stephen; Myers, Malcolm; Gadie, Brian; Nelson, Anthony J.; Pape, Robin; et al.
Journal of Medicinal Chemistry, 1988 , vol. 31, # 5 p. 902 - 906
反应条件
1: aqueous HCl; NaNO2 / Erwaermen nach Zusatz weiterer wss. HCl
2: palladium/charcoal; ethanol; triethylamine / Hydrogenation
View Scheme
参考文献
Hemmerich et al.
Helvetica Chimica Acta, 1958 , vol. 41, p. 2058,2065
