(2R,4S)-1-叔丁基 2-甲基 4-氨基吡咯烷-1,2-二甲酸酯合成路线 （共 6 条）
反应条件
formic acid; hydrogen; 10percent Pd/C in tetrahydrofuran; ethanol P=2792.67 Torr; 16 h;
参考文献
Natchus; Bookland; De; Almstead; Pikul; Janusz; Heitmeyer; Hookfin; Hsieh; Dowty; Dietsch; Patel; Garver; Gu; Pokross; Mieling; Baker; Foltz; Peng; Bornes; Strojnowski; Taiwo
Journal of Medicinal Chemistry, 2000 , vol. 43, # 26 p. 4948 - 4963
反应条件
1: Et3N; DMAP / H2O; acetone / 16 h 2: Et3N / CH2Cl2 / 20 °C 3: 59 percent / NaN3 / dimethylformamide / 26 h / 55 °C 4: 61 percent / H2; HCOOH / 10percent Pd/C / ethanol; tetrahydrofuran / 16 h / 2792.67 Torr View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 43, # 26 p. 4948 - 4963
反应条件
1: Et3N / CH2Cl2 / 20 °C 2: 59 percent / NaN3 / dimethylformamide / 26 h / 55 °C 3: 61 percent / H2; HCOOH / 10percent Pd/C / ethanol; tetrahydrofuran / 16 h / 2792.67 Torr View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 43, # 26 p. 4948 - 4963
反应条件
1: Et3N; DMAP / H2O; acetone / 16 h 2: Et3N / CH2Cl2 / 20 °C 3: 59 percent / NaN3 / dimethylformamide / 26 h / 55 °C 4: 61 percent / H2; HCOOH / 10percent Pd/C / ethanol; tetrahydrofuran / 16 h / 2792.67 Torr View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 43, # 26 p. 4948 - 4963
反应条件
1: 59 percent / NaN3 / dimethylformamide / 26 h / 55 °C 2: 61 percent / H2; HCOOH / 10percent Pd/C / ethanol; tetrahydrofuran / 16 h / 2792.67 Torr View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 43, # 26 p. 4948 - 4963
反应条件
1: NaN3 / dimethylformamide / 5 h / 50 °C 2: H2 / Pd/C / methanol / 4 h / 1551.4 Torr View Scheme
参考文献
Tetrahedron, , vol. 52, # 47 p. 15017 - 15030
