1: (1S,5R)-2-[(R)-2-phenylethyl]-6-oxa-2-azabicyclo[3.2.1]octan-7-one With hydrogenchloride; hydrogen; palladium 10 on activated carbon in 1,4-dioxane; methanol T=20°C; 2: With triethylamine in dichloromethane T=20°C; 0.25 h; 3: di-tert-butyl dicarbonate in dichloromethane T=20°C;

hydrogen; palladium on activated charcoal

sodium hydroxide in 1,4-dioxane

1.1: lipase AY30 from Candida rugosa 1.2: K2CO3 / methanol 2.1: 83 percent / H2 / Pd/C View Scheme

1.1: L-acylase / 65 °C / pH 8.0 1.2: 24 percent / pH 8.0 2.1: SOCl2 3.1: lipase AY30 from Candida rugosa 3.2: K2CO3 / methanol 4.1: 83 percent / H2 / Pd/C View Scheme

1.1: SOCl2 2.1: lipase AY30 from Candida rugosa 2.2: K2CO3 / methanol 3.1: 83 percent / H2 / Pd/C View Scheme

1.1: lipase AY30 from Candida rugosa 1.2: K2CO3 / methanol 2.1: 83 percent / H2 / Pd/C View Scheme

hydrogenchloride in methanol T=20°C;