3-(4-溴苯基)环丁烷酮合成路线 （共 5 条）
反应条件
acetic acid; zinc 5 h; Heating;
参考文献
Malkov, Andrei V.; Friscourt, Frederic; Bell, Mark; Swarbrick, Martin E.; Kocovsky, Pavel
Journal of Organic Chemistry, 2008 , vol. 73, # 11 p. 3996 - 4003
反应条件
1: N,N-dimethyl acetamide With trifluoromethylsulfonic anhydride in anhydrous dichloroethane T=-12°C; 2: 1-bromo-4-ethenylbenzene With 2,4,6-trimethyl-pyridine in anhydrous dichloroethane T=150°C; 3: With water in anhydrous dichloroethane T=80°C; 20 h;
参考文献
PFIZER INC.; ASPNES, Gary, Erik; DOW, Robert, Lee; MUNCHHOF, Michael, John
Patent: WO2010/86820 A1, 2010 ;
Location in patent: Page/Page column 43 ;
WO 2010/086820 A1
反应条件
1: Zn-Cu; POCl3 / diethyl ether / 4 h / 20 °C / Heating 2: Zn; AcOH / 2.5 h / 20 - 120 °C View Scheme
参考文献
Xu, Hua-Jian; Zhu, Feng-Fei; Shen, Yong-Ya; Wan, Xin; Feng, Yi-Si
Tetrahedron, 2012 , vol. 68, # 22 p. 4145 - 4151
反应条件
1.1: 82.5 percent / p-TsOH / benzene / 20 h / 120 °C 2.1: BuLi / hexane; tetrahydrofuran / 0.5 h / -70 °C 2.2: B(OiPr)3 / tetrahydrofuran; hexane / -70 - 20 °C 2.3: 83 percent / H2SO4 / H2O / 0.5 h / 0 °C View Scheme
参考文献
Srivastava, Rajiv R.; Singhaus, Robert R.; Kabalka, George W.
Journal of Organic Chemistry, 1999 , vol. 64, # 23 p. 8495 - 8500
反应条件
1.1: 82.5 percent / p-TsOH / benzene / 20 h / 120 °C 2.1: BuLi / hexane; tetrahydrofuran / 0.5 h / -70 °C 2.2: B(OiPr)3 / tetrahydrofuran; hexane / -70 - 20 °C 2.3: 83 percent / H2SO4 / H2O / 0.5 h / 0 °C 3.1: 79 percent / HCl / methanol / 20 °C View Scheme
参考文献
Srivastava, Rajiv R.; Singhaus, Robert R.; Kabalka, George W.
Journal of Organic Chemistry, 1999 , vol. 64, # 23 p. 8495 - 8500
