1: With n-butyllithium in tetrahydrofuran; hexane T=-70°C; Metallation; 0.5 h; 2: With tri-isopropoxy-borane in tetrahydrofuran; hexane T=-70 - 20°C; Substitution; 3: With sulfuric acid in water T=0°C; Hydrolysis; 0.5 h;

1.1: BuLi / hexane; tetrahydrofuran / 0.5 h / -70 °C 1.2: B(OiPr)3 / tetrahydrofuran; hexane / -70 - 20 °C 1.3: 83 percent / H2SO4 / H2O / 0.5 h / 0 °C 2.1: 79 percent / HCl / methanol / 20 °C View Scheme