(R)-α-(氨基甲基)苄醇合成路线 （共 67 条）
反应条件
1: 85 percent / NaN3 / dimethylformamide / 8 h / 100 °C 2: H2 / Pd/CaCO3 / ethyl acetate / 7 h / 25 °C / 2327.2 Torr View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 28, # 1 p. 47 - 61
反应条件
1: With borane-THF; C13H24BNO2 in tetrahydrofuran T=0 - 20°C; 3.5 h; 2: With methanol T=20°C; 24 h;
参考文献
Synthesis, , # 2 art. no. P14610SS, p. 316 - 324
反应条件
ammonia in methanol; water T=15 - 20°C; Title compound not separated from byproducts;
参考文献
Tetrahedron Asymmetry, , vol. 14, # 21 p. 3297 - 3300
反应条件
1: I2 / tetrahydrofuran 2: 88 percent / LiAlH4 / tetrahydrofuran / 4 h / 0 °C View Scheme
参考文献
Chemistry - A European Journal, , vol. 11, # 13 p. 3849 - 3862
反应条件
1: pyridine / 10 h / Ambient temperature 2: H2O; ethanol / 504 h / 32 °C / baker's yeast, sucrose 3: 10percent aq. HCl / methanol View Scheme
参考文献
Bulletin of the Chemical Society of Japan, , vol. 66, # 4 p. 1216 - 1221
反应条件
1: With dimethylsulfide borane complex; C10H18BNO in tetrahydrofuran T=0°C; Reflux; 2: With hydrogenchloride; water in tetrahydrofuran T=20°C; 5 h; optical yield given as percent eeenantioselective reaction;
参考文献
Synthesis, , # 2 art. no. P14610SS, p. 316 - 324
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=0 - 50°C;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 24, # 5 p. 1280 - 1284
反应条件
1: 76 percent / pyridine / 4 h / -10 °C 2: 93 percent / NaN3 / dimethylformamide / 2 h / 90 - 95 °C 3: 90 percent / LiAlH4 / diethyl ether / 3 h / Heating View Scheme
参考文献
Journal of Organic Chemistry, , vol. 62, # 4 p. 827 - 835
反应条件
1: 93 percent / NaN3 / dimethylformamide / 2 h / 90 - 95 °C 2: 90 percent / LiAlH4 / diethyl ether / 3 h / Heating View Scheme
参考文献
Journal of Organic Chemistry, , vol. 62, # 4 p. 827 - 835
