(R)-α-(氨基甲基)苄醇合成路线 （共 67 条）
反应条件
1: 1.) titanium tetrachloride / 1.) dichloromethane, -78 deg C, 25 min, 2.) -78 deg C, 45 min 2: BH3*THF / 4 h / Heating 3: 90 percent / tetrahydrofuran / 0.75 h / Heating 4: 1.) pyridinium dichromate, 2.) 2,5 M aq. KOH / 1.) CH2Cl2, 25 deg C, 18 h, 2.) THF, MeOH, 25 deg C, 5 h 5: TFA / H2O / 0.5 h / 25 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 48, # 13 p. 2294 - 2295
反应条件
1: 90 percent / tetrahydrofuran / 0.75 h / Heating 2: 1.) pyridinium dichromate, 2.) 2,5 M aq. KOH / 1.) CH2Cl2, 25 deg C, 18 h, 2.) THF, MeOH, 25 deg C, 5 h 3: TFA / H2O / 0.5 h / 25 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 48, # 13 p. 2294 - 2295
反应条件
1: 1.) pyridinium dichromate, 2.) 2,5 M aq. KOH / 1.) CH2Cl2, 25 deg C, 18 h, 2.) THF, MeOH, 25 deg C, 5 h 2: TFA / H2O / 0.5 h / 25 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 48, # 13 p. 2294 - 2295
反应条件
1: BH3*THF / 4 h / Heating 2: 90 percent / tetrahydrofuran / 0.75 h / Heating 3: 1.) pyridinium dichromate, 2.) 2,5 M aq. KOH / 1.) CH2Cl2, 25 deg C, 18 h, 2.) THF, MeOH, 25 deg C, 5 h 4: TFA / H2O / 0.5 h / 25 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 48, # 13 p. 2294 - 2295
反应条件
1: With dimethylsulfide borane complex; C10H18BNO in tetrahydrofuran T=0°C; Reflux; 2: With hydrogenchloride; water in tetrahydrofuran T=20°C; 5 h; optical yield given as percent ee;
参考文献
Synthesis, , # 2 art. no. P14610SS, p. 316 - 324
反应条件
1: With dimethylsulfide borane complex; C10H18BNO in tetrahydrofuran T=0°C; Reflux; 2: With hydrogenchloride; water in tetrahydrofuran T=20°C; 5 h; optical yield given as percent ee;
参考文献
Synthesis, , # 2 art. no. P14610SS, p. 316 - 324
反应条件
1: With dimethylsulfide borane complex; C13H24BNO2 in tetrahydrofuran T=0°C; Reflux; 2: With hydrogenchloride; water in tetrahydrofuran T=20°C; 5 h; optical yield given as percent ee;
参考文献
Synthesis, , # 2 art. no. P14610SS, p. 316 - 324
反应条件
yeast Saccharomyces cerevisiae optical yield given as percent ee;
参考文献
Bosiak, Mariusz J.; Pakulski, Marcin M.
Synthesis, 2011 , # 2 art. no. P14610SS, p. 316 - 324
反应条件
1: H2O; ethanol / 504 h / 32 °C / baker's yeast, sucrose 2: 10percent aq. HCl / methanol View Scheme
参考文献
Bulletin of the Chemical Society of Japan, , vol. 66, # 4 p. 1216 - 1221
反应条件
1.1: silver(l) oxide / dichloromethane / 0 - 20 °C 2.1: C10H18BNO; dimethylsulfide borane complex / tetrahydrofuran / 0 °C / Reflux 2.2: 5 h / 20 °C View Scheme
参考文献
Synthesis, , # 2 art. no. P14610SS, p. 316 - 324
