2-甲基咪唑并[1,2-a]吡啶-3-甲酸乙酯合成路线 （共 11 条）
反应条件
in ethanol 20 h; Heating;
参考文献
Ribeiro, Izabella G.; Da Silva, Kelly Christine M.; Parrini, Sergio C.; De Miranda, Ana Luisa P.; Fraga, Carlos A. M.; Barreiro, Eliezer J.
European Journal of Medicinal Chemistry, 1998 , vol. 33, # 3 p. 225 - 235
反应条件
in neat (no solvent) T=20°C; 4 h;
参考文献
Attanasi, Orazio A.; Bianchi, Luca; Campisi, Linda A.; Crescentini, Lucia De; Favi, Gianfranco; Mantellini, Fabio
Organic Letters, 2013 , vol. 15, # 14 p. 3646 - 3649
反应条件
T=55°C; 0.166667 h; neat (no solvent);
参考文献
Chunavala, Kaushik C.; Joshi, Girdhar; Suresh, Eringathodi; Adimurthy, Subbarayappa
Synthesis, 2011 , # 4 art. no. Z27510SS, p. 635 - 641
反应条件
1: titanium tetrachloride 2: potassium carbonate View Scheme
参考文献
Tetrahedron Letters, , vol. 53, # 21 p. 2583 - 2587
参考文献
Tetrahedron Letters, , vol. 53, # 21 p. 2583 - 2587
反应条件
morpholine; bis(2-methoxyethoxy)aluminum hydride in toluene T=-55 - -40°C; 0.5 h;
参考文献
Lima, Patricia C; Avery, Mitchell A; Tekwani, Babu L; de Alves, Helio M; Barreiro, Eliezer J; Fraga, Carlos A M
Farmaco (Societa chimica italiana : 1989), 2002 , vol. 57, # 10 p. 825 - 832
反应条件
hydrazine hydrate in ethanol T=70°C; 3 h;
参考文献
Kuemmerle, Arthur E.; Schmitt, Martine; Cardozo, Suzana V. S.; Lugnier, Claire; Villa, Pascal; Lopes, Alexandra B.; Romeiro, Nelilma C.; Justiniano, Helene; Martins, Marco A.; Fraga, Carlos A. M.; Bourguignon, Jean-Jacques; Barreiro, Eliezer J.
Journal of Medicinal Chemistry, 2012 , vol. 55, # 17 p. 7525 - 7545
反应条件
water; potassium hydroxide in methanol T=70°C; 5 h;
参考文献
Kuemmerle, Arthur E.; Schmitt, Martine; Cardozo, Suzana V. S.; Lugnier, Claire; Villa, Pascal; Lopes, Alexandra B.; Romeiro, Nelilma C.; Justiniano, Helene; Martins, Marco A.; Fraga, Carlos A. M.; Bourguignon, Jean-Jacques; Barreiro, Eliezer J.
Journal of Medicinal Chemistry, 2012 , vol. 55, # 17 p. 7525 - 7545
反应条件
lithium aluminium tetrahydride in tetrahydrofuran 1) 0 deg C to 22 deg C, 2) 22 deg C, 1 h;
参考文献
Starrett Jr.; Montzka; Crosswell; Cavanagh
Journal of Medicinal Chemistry, 1989 , vol. 32, # 9 p. 2204 - 2210
反应条件
1.1: 60 percent / bis(2-methoxyethoxy)aluminum hydride; morpholine / toluene / 0.5 h / -55 - -40 °C
2.1: n-BuLi / tetrahydrofuran; hexane
2.2: 60 percent / tetrahydrofuran; hexane / 2.5 h
3.1: 87 percent / MnO2 / CH2Cl2 / 2.5 h / 20 °C
View Scheme
参考文献
Lima, Patricia C; Avery, Mitchell A; Tekwani, Babu L; de Alves, Helio M; Barreiro, Eliezer J; Fraga, Carlos A M
Farmaco (Societa chimica italiana : 1989), 2002 , vol. 57, # 10 p. 825 - 832
