(S)-3-(二甲基氨基甲基)-N-叔丁氧羰基-哌啶合成路线 （共 6 条）
反应条件
ammonium hydroxide; sodium hydroxide; sodium tris(acetoxy)borohydride; acetic acid; dimethyl amine in methanol; ethanol; dichloromethane; tert-butyl methyl ether
参考文献
Novo Nordisk A/S
Patent: US6919315 B1, 2005 ;
反应条件
diisobutylaluminium hydride in diethyl ether; water; toluene
参考文献
Novo Nordisk A/S
Patent: US6919315 B1, 2005 ;
反应条件
sodium tris(acetoxy)borohydride in dichloromethane; water 4 h;
参考文献
Helicon Therapeutics, Inc.
Patent: US2009/62252 A1, 2009 ;
Location in patent: Page/Page column 42 ;
US 20090062252 A1
反应条件
molecular sieve; sodium tris(acetoxy)borohydride; acetic acid in ethanol; dichloromethane T=20°C; 16 h;
参考文献
Peschke, Bernd; Ankersen, Michael; Bauer, Michael; Hansen, Thomas Kruse; Hansen, Birgit Sehested; Nielsen, Karin Kramer; Raun, Kirsten; Richter, Lutz; Westergaard, Lisbet
European Journal of Medicinal Chemistry, 2002 , vol. 37, # 6 p. 487 - 501
反应条件
1: 4.13 g / aq. NaOH / tetrahydrofuran / 16 h / 20 °C 2: DIBAL / toluene; diethyl ether / 2.5 h / -78 °C 3: 866 mg / NaB(OAc)3H; AcOH; molecular sieves / CH2Cl2; ethanol / 16 h / 20 °C View Scheme
参考文献
Peschke, Bernd; Ankersen, Michael; Bauer, Michael; Hansen, Thomas Kruse; Hansen, Birgit Sehested; Nielsen, Karin Kramer; Raun, Kirsten; Richter, Lutz; Westergaard, Lisbet
European Journal of Medicinal Chemistry, 2002 , vol. 37, # 6 p. 487 - 501
反应条件
1: DIBAL / toluene; diethyl ether / 2.5 h / -78 °C 2: 866 mg / NaB(OAc)3H; AcOH; molecular sieves / CH2Cl2; ethanol / 16 h / 20 °C View Scheme
参考文献
Peschke, Bernd; Ankersen, Michael; Bauer, Michael; Hansen, Thomas Kruse; Hansen, Birgit Sehested; Nielsen, Karin Kramer; Raun, Kirsten; Richter, Lutz; Westergaard, Lisbet
European Journal of Medicinal Chemistry, 2002 , vol. 37, # 6 p. 487 - 501
