1,4-苯并二氧杂环己烷合成路线 （共 15 条）
反应条件
Grubb's 2nd generation catalyst in toluene T=80°C; 18 h; Inert atmosphere;
参考文献
Morgans, Garreth L.; Ngidi, E. Lindani; Madeley, Lee G.; Khanye, Setshaba D.; Michael, Joseph P.; de Koning, Charles B.; van Otterlo, Willem A.L.
Tetrahedron, 2009 , vol. 65, # 51 p. 10650 - 10659
反应条件
N-bromosuccinmide in tetrachloromethane
参考文献
Adir et Compagnie
Patent: US5807882 A1, 1998 ;
反应条件
1: 76 percent / K2CO3 / acetone / Heating 2: [RuClH(CO)(PPh3)3] / toluene-d8 / 80 °C 3: Grubbs' catalyst / toluene-d8 View Scheme
参考文献
Kashima, Choji; Tomotake, Atsushi; Omote, Yoshimori
Journal of Organic Chemistry, 1987 , vol. 52, # 25 p. 5616 - 5621
反应条件
bis(tricyclohexylphosphine)benzylidene ruthenium(IV) dichloride in toluene T=70 - 80°C;
参考文献
Van Otterlo, Willem A. L.; Ngidi, E. Lindani; De Koning, Charles B.
Tetrahedron Letters, 2003 , vol. 44, # 34 p. 6483 - 6486
反应条件
1: [RuClH(CO)(PPh3)3] / toluene-d8 / 80 °C 2: Grubbs' catalyst / toluene-d8 View Scheme
参考文献
Van Otterlo, Willem A. L.; Ngidi, E. Lindani; De Koning, Charles B.
Tetrahedron Letters, 2003 , vol. 44, # 34 p. 6483 - 6486
反应条件
1: CH2Cl2 / 1 h / -78 °C / Irradiation 2: potassium carbonate / ethane-1,2-diol / 4 h / 120 °C 3: 1.) N-bromosuccinimide (NBS), AIBN, 2.) NaI / 1.) carbon tetrachloride, 12 h, reflux, 2.) acetone, 2 h, reflux View Scheme
参考文献
Kashima, Choji; Tomotake, Atsushi; Omote, Yoshimori
Journal of Organic Chemistry, 1987 , vol. 52, # 25 p. 5616 - 5621
反应条件
1: 51 percent / CH2Cl2 / 1 h / -78 °C / Irradiation 2: potassium carbonate / ethane-1,2-diol / 4 h / 120 °C 3: 1.) N-bromosuccinimide (NBS), AIBN, 2.) NaI / 1.) carbon tetrachloride, 12 h, reflux, 2.) acetone, 2 h, reflux View Scheme
参考文献
Kashima, Choji; Tomotake, Atsushi; Omote, Yoshimori
Journal of Organic Chemistry, 1987 , vol. 52, # 25 p. 5616 - 5621
反应条件
N-bromosuccinmide; 2,2'-azo-bisisobutyronitrile; sodium iodide 1.) carbon tetrachloride, 12 h, reflux, 2.) acetone, 2 h, reflux; Multistep reaction;
参考文献
Dorrestijn, Edwin; Epema, Onno J.; Van Scheppingen, Wibo B.; Mulder, Peter
Journal of the Chemical Society. Perkin Transactions 2, 1998 , # 5 p. 1173 - 1178
反应条件
sodium iodide in acetone Heating; Yield given;
参考文献
Dorrestijn, Edwin; Epema, Onno J.; Van Scheppingen, Wibo B.; Mulder, Peter
Journal of the Chemical Society. Perkin Transactions 2, 1998 , # 5 p. 1173 - 1178
参考文献
Fujita et al.
Yakugaku Zasshi, 1956 , vol. 76, p. 1097
Chem.Abstr., 1957 , p. 2791
