(S)-(+)-1-茚醇合成路线 (共 57 条)
反应条件
PdCl2(nbd); oxygen; (-)-sparteine; 3 A molecular sieve in toluene T=60°C; P=760.051 Torr; 54 h;
参考文献
Dearden, Michael J.; Firkin, Catherine R.; Hermet, Jean-Paul R.; O'Brien, Peter
Journal of the American Chemical Society, 2002 , vol. 124, # 40 p. 11870 - 11871
反应条件
dimethylsulfide borane complex; (R)-tetrahydro-1-methyl-3,3-diphenyl-1H,3H-pyrrolo[1,2-c]-[1,3,2]oxazaborole in tetrahydrofuran T=0°C; 0.5 h; enantioselective reaction;
参考文献
Teitelbaum, Aaron M.; Meissner, Anja; Harding, Ryan A.; Wong, Christopher A.; Aldrich, Courtney C.; Remmel, Rory P.
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 17 p. 5605 - 5617
反应条件
palladium dichloro (η-2,5-norbornadiene); oxygen; (-)-sparteine in toluene T=60°C; 54 h; Title compound not separated from byproducts;
参考文献
Ferreira; Stoltz
Journal of the American Chemical Society, 2001 , vol. 123, # 31 p. 7725 - 7726
反应条件
dimethylsulfide borane complex; (S)-2-(anilinodiphenylmethyl)pyrrolidine in tetrahydrofuran T=20°C; 2 h; enantioselective reaction;
参考文献
Hosoda, Naoya; Kamito, Hideaki; Takano, Miki; Takebe, Yoshitaka; Yamaguchi, Yoshitaka; Asami, Masatoshi
Tetrahedron, 2013 , vol. 69, # 6 p. 1739 - 1746
反应条件
sodium hydrogencarbonate; sodium bromide; chiral azabicyclo-N-oxyl in dichloromethane T=0°C; Electrochemical reaction;
参考文献
Shiigi, Hirofumi; Mori, Hiroyuki; Tanaka, Tomoaki; Demizu, Yosuke; Onomura, Osamu
Tetrahedron Letters, 2008 , vol. 49, # 36 p. 5247 - 5251
反应条件
potassium hydroxide in ethanol T=25°C; 18 h;
参考文献
Lin, Gialih; Lin, Wen-Yuan; Shieh, Chuen-Tzwu
Tetrahedron Letters, 1998 , vol. 39, # 48 p. 8881 - 8884
反应条件
1: With succinic acid anhydride; Candida antarctica lipase B in diethyl ether T=20°C; Enzymatic reaction; 2: With sodium hydroxide in water
参考文献
Bouzemi, Nassima; Debbeche, Hanane; Aribi-Zouioueche, Louisa; Fiaud, Jean-Claude
Tetrahedron Letters, 2004 , vol. 45, # 3 p. 627 - 630
反应条件
[(C4Ph4COHOCC4Ph4)(μ-H)][(CO)4Ru2]; Novozym(R) 435; 2,4-dimethylpentan-3-one in toluene T=70°C; P=142.511 Torr; 40 h;
参考文献
Verzijl, Gerard K.M.; De Vries, Johannes G.; Broxterman, Quirinus B.
Tetrahedron Asymmetry, 2005 , vol. 16, # 9 p. 1603 - 1610
反应条件
rhodium complex of 1-(2-diphenylphosphino-1-naphthyl)isoquinoline; dihydrogen peroxide; benzo[1,3,2]dioxaborole 1.) THF, 20 deg C; Yield given. Multistep reaction. Title compound not separated from byproducts;
参考文献
Journal of the Chemical Society, Chemical Communications, , # 22 p. 1673 - 1674
反应条件
2,6-dichloropyridine-N-oxide in benzene T=20°C; 6 h;
参考文献
Tetrahedron Asymmetry, , vol. 16, # 21 p. 3520 - 3526