(S)-(+)-1-茚醇合成路线 （共 57 条）
反应条件
1: 1-hydroxyindan With iPr2NCHEt2; (-)-Tetramisole in tetrahydrofuran T=-78°C; 0.5 h; Molecular sieveInert atmosphereResolution of racemate; 2: diphenyl(methyl)silyl chloride in tetrahydrofuran T=-78°C; 12 h; Inert atmosphereResolution of racemate; enantioselective reaction;
参考文献
Sheppard, Cody I.; Taylor, Jessica L.; Wiskur, Sheryl L.
Organic Letters, 2011 , vol. 13, # 15 p. 3794 - 3797
反应条件
1: 1-hydroxyindan With iPr2NCHEt2; (-)-Tetramisole in tetrahydrofuran T=-78°C; 0.5 h; Molecular sieveInert atmosphereResolution of racemate; 2: triethylsilyl chloride in tetrahydrofuran T=-78°C; 12 h; Inert atmosphereResolution of racemate; enantioselective reaction;
参考文献
Sheppard, Cody I.; Taylor, Jessica L.; Wiskur, Sheryl L.
Organic Letters, 2011 , vol. 13, # 15 p. 3794 - 3797
反应条件
1: 1-hydroxyindan With iPr2NCHEt2; (-)-Tetramisole in tetrahydrofuran T=-78°C; 0.5 h; Molecular sieveInert atmosphereResolution of racemate; 2: dimethyl(phenyl)silyl chloride in tetrahydrofuran T=-78°C; 12 h; Inert atmosphereResolution of racemate; enantioselective reaction;
参考文献
Sheppard, Cody I.; Taylor, Jessica L.; Wiskur, Sheryl L.
Organic Letters, 2011 , vol. 13, # 15 p. 3794 - 3797
反应条件
Pseudomonas fluorescens lipase [E.(1)C313] in diethyl ether T=20°C; 48 h; Enzymatic reaction;
参考文献
Bouzemi, Nassima; Debbeche, Hanane; Aribi-Zouioueche, Louisa; Fiaud, Jean-Claude
Tetrahedron Letters, 2004 , vol. 45, # 3 p. 627 - 630
反应条件
1: With (S)-2-methyl-quinazolinap rhodium; benzo[1,3,2]dioxaborole in tetrahydrofuran T=20°C; 2 h; 2: With sodium hydroxide; dihydrogen peroxide in tetrahydrofuran; ethanol T=0 - 20°C;
参考文献
Journal of Organic Chemistry, , vol. 69, # 20 p. 6572 - 6589
反应条件
tetrabutyl ammonium fluoride in tetrahydrofuran T=20°C; 10 h; Inert atmosphere; optical yield given as percent ee;
参考文献
Organic Letters, , vol. 13, # 15 p. 3794 - 3797
反应条件
lipase B from Candida antarctica in cyclohexane T=50°C; 0.5 h; Resolution of racemate; optical yield given as percent ee;
参考文献
Li, Xiang; Shi, Yi; Wang, Zhoujun; Zhang, Yahong; Tang, Yi
Journal of Catalysis, 2012 , vol. 288, p. 24 - 32
反应条件
1: With (R)-2-tert-butyl-quinazolinap rhodium; benzo[1,3,2]dioxaborole in tetrahydrofuran T=0°C; 2 h; 2: With sodium hydroxide; dihydrogen peroxide in tetrahydrofuran; ethanol T=0 - 20°C; Title compound not separated from byproducts;
参考文献
Journal of Organic Chemistry, , vol. 69, # 20 p. 6572 - 6589
反应条件
SPB; water in tetrahydrofuran T=20°C; Inert atmosphere;
参考文献
Chemistry - An Asian Journal, , vol. 6, # 8 p. 1967 - 1969
反应条件
1: 1-hydroxyindan With iPr2NCHEt2; (-)-Tetramisole in tetrahydrofuran T=-78°C; 0.5 h; Molecular sieveInert atmosphereResolution of racemate; 2: triphenyl-silyl chloride in tetrahydrofuran T=-78°C; 1 h; Inert atmosphereResolution of racemate; optical yield given as percent eeenantioselective reaction;
参考文献
Organic Letters, , vol. 13, # 15 p. 3794 - 3797
