1-乙酰基-4-哌啶甲酸合成路线 （共 25 条）
参考文献
US6218404 B1, ;
US 6218404 B1
参考文献
WO2010/6962 A1, ;
Page/Page column 32-33 ;
WO 2010/006962 A1
反应条件
sodium iodide; sodium carbonate in hydrogen bromide
反应条件
1: SOCl2 / 1 h / 20 °C 2: AlCl3 / 1,2-dichloro-ethane / 2 h / Heating 3: aq. HCl / Heating View Scheme
参考文献
Orjales, Aurelio; Mosquera, Ramon; Toledo, Antonio; Pumar, M. Carmen; Garcia, Neftali; Cortizo, Lourdes; Labeaga, Luis; Innerarity, Ana
Journal of Medicinal Chemistry, 2003 , vol. 46, # 25 p. 5512 - 5532
反应条件
1: SOCl2 / 1 h / 20 °C 2: AlCl3 / 1,2-dichloro-ethane / Heating 3: aq. HCl / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 46, # 25 p. 5512 - 5532
反应条件
sodium hydroxide; hydrazine hydrate; aluminium chloride in thionyl chloride; o-di-fluorobenzene; diethyl ether; ethanol; di-isopropyl ether; water; ethylene glycol; Petroleum ether
参考文献
Synthelabo
Patent: US4690931 A1, 1987 ;
反应条件
1: AlCl3 2: HCl 3: Et3SiH View Scheme
参考文献
Chumpradit, S.; Choi, S. R.; Hou, C.; Acton, P. D.; Kung, H. F.
Journal of Labelled Compounds and Radiopharmaceuticals, 2001 , vol. 44, p. S524 - S526
反应条件
1: 1-Acetyl-piperidine-4-carboxylic acid With thionyl chloride in 1,2-dichloro-ethane T=20°C; 1 h; 2: o-di-fluorobenzene With AlCl3, aluminium chloride in 1,2-dichloro-ethane T=80°C; 3 h;
参考文献
PIERRE FABRE MEDICAMENT; LEROY, Isabelle; DUPONT-PASSELAIGUE, Elisabeth; VALEILLE, Karine; RIVAL, Yves; JUNQUERO, Didier
Patent: WO2010/6962 A1, 2010 ;
Location in patent: Page/Page column 32-33 ;
WO 2010/006962 A1
反应条件
1: SOCl2 / 1 h / 20 °C 2: 6.4 g / AlCl3 / 1,2-dichloro-ethane / 2 h / Heating View Scheme
参考文献
Adir et Compagnie
Patent: US5387586 A1, 1995 ;
反应条件
1: SOCl2 / 1,2-dichloro-ethane / 0.33 h / 60 °C 2: AlCl3 / 1,2-dichloro-ethane / 4 h / Heating View Scheme
参考文献
Watanabe; Yoshiwara; Kanao
Journal of Heterocyclic Chemistry, 1993 , vol. 30, # 2 p. 445 - 451
