1-乙酰基-4-哌啶甲酸合成路线 （共 25 条）
反应条件
1: SOCl2 / 1 h / 20 °C 2: AlCl3 / 1,2-dichloro-ethane / 2 h / Heating View Scheme
参考文献
Orjales, Aurelio; Mosquera, Ramon; Toledo, Antonio; Pumar, M. Carmen; Garcia, Neftali; Cortizo, Lourdes; Labeaga, Luis; Innerarity, Ana
Journal of Medicinal Chemistry, 2003 , vol. 46, # 25 p. 5512 - 5532
反应条件
thionyl chloride T=20°C; 2 h;
参考文献
Takeda Chemical Industries, Ltd.
Patent: EP1359145 A1, 2003 ;
Location in patent: Page/Page column 34-35 ;
参考文献
Warner-Lambert Co.; Cocensys, Inc.
Patent: US6218404 B1, 2001 ;
US 6218404 B1
反应条件
1: SOCl2 / 1 h / 20 °C 2: 6.4 g / AlCl3 / 1,2-dichloro-ethane / 2 h / Heating 3: aq. HCl / Heating View Scheme
参考文献
Chumpradit, S.; Choi, S. R.; Hou, C.; Acton, P. D.; Kung, H. F.
Journal of Labelled Compounds and Radiopharmaceuticals, 2001 , vol. 44, p. S524 - S526
参考文献
MERCK and CO., INC.
Patent: WO2007/81897 A2, 2007 ;
Location in patent: Page/Page column 24 ;
WO 2007/081897 A2
反应条件
1: SOCl2 / 1 h / 20 °C 2: AlCl3 / 1,2-dichloro-ethane / Heating 3: aq. HCl / Heating 4: aq. NaHCO3 / 20 °C View Scheme
参考文献
Orjales, Aurelio; Mosquera, Ramon; Toledo, Antonio; Pumar, M. Carmen; Garcia, Neftali; Cortizo, Lourdes; Labeaga, Luis; Innerarity, Ana
Journal of Medicinal Chemistry, 2003 , vol. 46, # 25 p. 5512 - 5532
反应条件
1: SOCl2 / 1 h / 20 °C 2: 6.4 g / AlCl3 / 1,2-dichloro-ethane / 2 h / Heating 3: aq. HCl / Heating 4: aq. NaHCO3 / 20 °C View Scheme
参考文献
Orjales, Aurelio; Mosquera, Ramon; Toledo, Antonio; Pumar, M. Carmen; Garcia, Neftali; Cortizo, Lourdes; Labeaga, Luis; Innerarity, Ana
Journal of Medicinal Chemistry, 2003 , vol. 46, # 25 p. 5512 - 5532
反应条件
1: SOCl2 / 1 h / 20 °C 2: AlCl3 / 1,2-dichloro-ethane / 2 h / Heating 3: aq. HCl / Heating 4: aq. NaHCO3 / 20 °C View Scheme
参考文献
Orjales, Aurelio; Mosquera, Ramon; Toledo, Antonio; Pumar, M. Carmen; Garcia, Neftali; Cortizo, Lourdes; Labeaga, Luis; Innerarity, Ana
Journal of Medicinal Chemistry, 2003 , vol. 46, # 25 p. 5512 - 5532
反应条件
thionyl chloride; aluminium trichloride in anhydrous dichloroethane
参考文献
Hoechst-Roussel Pharmaceuticals
Patent: US4355037 A1, 1982 ;
反应条件
1: SOCl2 / 1,2-dichloro-ethane / 40 - 65 °C
2: AlCl3 / 1,2-dichloro-ethane / 4 h / Heating
View Scheme
参考文献
Strupczewski, Joseph T.; Allen, Richard C.; Gardner, Beth Ann; Schmid, Blaine L.; Stache, Ulrich; et al.
Journal of Medicinal Chemistry, 1985 , vol. 28, # 6 p. 761 - 769
