环己基-L-丙氨酸盐酸盐合成路线 （共 14 条）
反应条件
triethylamine in 1,4-dioxane; water 4.5 h; Ambient temperature;
参考文献
Tsuda, Makoto; Muraoka, Yasuhiko; Nagai, Machiko; Aoyagi, Takaaki; Takeuchi, Tomio
Journal of Antibiotics, 1996 , vol. 49, # 9 p. 909 - 920
反应条件
thionyl chloride T=-10 - 20°C; 16 h;
参考文献
European Journal of Medicinal Chemistry, , vol. 68, p. 253 - 259
反应条件
hydrogenchloride; hydrogen; Rh/C in water
T=60°C; P=2585.81 Torr; 48 h;
参考文献
VITAE PHARAMCEUTICALS, INC.
Patent: WO2007/117557 A2, 2007 ;
Location in patent: Page/Page column 90-91 ;
WO 2007/117557 A2
反应条件
hydrogenchloride
4 h; Heating;
参考文献
Zaidan Hojin Biseibutsu Kagaku Kenkyukai
Patent: US5756763 A1, 1998 ;
反应条件
1: 98.1 percent / H2 / 5percent Rh-Al2O3 / methanol / 56 h / Ambient temperature
2: 96.6 percent / 7 N HCl / 4 h / Heating
View Scheme
参考文献
Tsuda, Makoto; Muraoka, Yasuhiko; Nagai, Machiko; Aoyagi, Takaaki; Takeuchi, Tomio
Journal of Antibiotics, 1996 , vol. 49, # 9 p. 909 - 920
反应条件
1: LiN(i-Pr)2 / 1 h / -78 °C
2: TiCl4, Ti(i-PrO)4 / CH2Cl2 / 1 h / -78 °C
3: 1.) CF3COOH 2.) hydrogen / 2.) PtO2 / 1.) CH2Cl2, 0 deg C --> r.t., 3 h 2.) EtOH, 75 psi, r.t., 24 h
4: 1.) Ti(EtO)4 2.) 6N aq. HCl / 1.) EtOH, 70 deg C, 3 h 2.) reflux
View Scheme
参考文献
Oppolzer, Wolfgang; Moretti, Robert
Helvetica Chimica Acta, 1986 , vol. 69, p. 1923 - 1926
反应条件
hydrogenchloride
24 h; Reflux;
参考文献
Ager, David J.; Prakash, Indra
Organic Process Research and Development, 2003 , vol. 7, # 2 p. 164 - 167
反应条件
1: hydrogenchloride / methanol / 4 h / 20 °C
2: hydrogenchloride / 24 h / |Reflux
View Scheme
参考文献
Ager, David J.; Prakash, Indra
Organic Process Research and Development, 2003 , vol. 7, # 2 p. 164 - 167
反应条件
1: 5 rhodium-on-charcoal; hydrogen / methanol; water / 16 h / 60 °C / 2828.7 - 3087.28 Torr
2: hydrogenchloride / methanol / 4 h / 20 °C
3: hydrogenchloride / 24 h / |Reflux
View Scheme
参考文献
Ager, David J.; Prakash, Indra
Organic Process Research and Development, 2003 , vol. 7, # 2 p. 164 - 167
反应条件
1: 1.) CF3COOH 2.) hydrogen / 2.) PtO2 / 1.) CH2Cl2, 0 deg C --> r.t., 3 h 2.) EtOH, 75 psi, r.t., 24 h
2: 1.) Ti(EtO)4 2.) 6N aq. HCl / 1.) EtOH, 70 deg C, 3 h 2.) reflux
View Scheme
参考文献
Oppolzer, Wolfgang; Moretti, Robert
Helvetica Chimica Acta, 1986 , vol. 69, p. 1923 - 1926
