2-(2-(4-氯苯氧基)苯基)乙酸合成路线 （共 17 条）
反应条件
1: With potassium hydroxide in methanol T=60°C; 3 h; 2: With hydrogenchloride in water pH=1;
参考文献
Organon Ireland Ltd.; Pfizer Inc.
Patent: US2006/229352 A1, 2006 ;
Location in patent: Page/Page column 7-8 ;
反应条件
1: With caesium carbonate; glycine; copper(l) chloride in 1,4-dioxane 120 h; Reflux; 2: With hydrogenchloride in water; ethyl acetate pH=1;
参考文献
Medichem, S.A.
Patent: EP2468751 A2, 2012 ;
Location in patent: Page/Page column 15-16 ;
反应条件
potassium carbonate; copper(l) chloride in toluene T=20 - 110°C; 21 h; Inert atmosphere;
参考文献
MSN LABORATORIES LIMITED; SATYANARAYANA REDDY, Manne; THIRUMALAI RAJAN, Srinivasan; ESWARAIAH, Sajja; MADHU, Elevathingal Nicholas; SATYANARAYANA, Komati; SEETHA RAMA SARMA, Peri
Patent: WO2012/38975 A2, 2012 ;
Location in patent: Page/Page column 35 ;
反应条件
potassium hydroxide in ethanol; water 3 h; Heating;
参考文献
Ong; Profitt; Anderson; Spaulding; Wilker; Geyer IIIrd; Kruse
Journal of Medicinal Chemistry, 1980 , vol. 23, # 5 p. 494 - 501
反应条件
potassium hydroxide in methanol 72 h; Heating;
参考文献
Journal of Medicinal Chemistry, , vol. 26, # 10 p. 1353 - 1360
反应条件
1: 60 percent / K2CO3, Cu / 10 h / Heating 2: sulfur / 12 h / Heating 3: glacial acetic acid, conc. aq. HCl / 8 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 25, # 7 p. 855 - 858
反应条件
1: sulfur / 12 h / Heating 2: glacial acetic acid, conc. aq. HCl / 8 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 25, # 7 p. 855 - 858
反应条件
1: 4-chlorophenol, copper / 24 h / 120 - 125 °C 2: sulfur / 24 h / Heating 3: KOH / methanol / 72 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 26, # 10 p. 1353 - 1360
反应条件
1: 60 percent / K2CO3, Cu / 10 h / Heating 2: sulfur / 12 h / Heating 3: glacial acetic acid, conc. aq. HCl / 8 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 25, # 7 p. 855 - 858
反应条件
1: (i) K2CO3, PhNO2, (ii) /BRN= 507004/ 2: LiAlH4 / diethyl ether 3: SOCl2, Py 4: (i) aq. EtOH, (ii) aq. KOH View Scheme
参考文献
Collection of Czechoslovak Chemical Communications, , vol. 34, # 8 p. 2258 - 2277
