2-(2-(4-氯苯氧基)苯基)乙酸合成路线 （共 17 条）
反应条件
1: LiAlH4 / diethyl ether 2: SOCl2, Py 3: (i) aq. EtOH, (ii) aq. KOH View Scheme
参考文献
Collection of Czechoslovak Chemical Communications, , vol. 34, # 8 p. 2258 - 2277
反应条件
1: SOCl2, Py 2: (i) aq. EtOH, (ii) aq. KOH View Scheme
参考文献
Collection of Czechoslovak Chemical Communications, , vol. 34, # 8 p. 2258 - 2277
反应条件
(i) aq. EtOH, (ii) aq. KOH; Multistep reaction;
参考文献
Collection of Czechoslovak Chemical Communications, , vol. 34, # 8 p. 2258 - 2277
反应条件
1: thionyl chloride / toluene / 1 h / 50 °C 2: triethylamine / N,N-dimethyl-formamide; toluene / 2.17 h / 5 - 20 °C View Scheme
参考文献
Medichem, S.A.
Patent: EP2468751 A2, 2012 ;
反应条件
1.1: thionyl chloride / N,N-dimethyl-formamide; toluene / 40 - 50 °C 1.2: 0 - 30 °C 2.1: potassium tert-butylate / toluene / 15 - 30 °C / Inert atmosphere 2.2: 0 - 5 °C / pH 2 - 2.5 3.1: phosphorus pentoxide; phosphoric acid / 100 - 120 °C 4.1: magnesium / methanol / 25 - 65 °C / Reflux 5.1: lithium aluminium tetrahydride; AlCl3, aluminium chloride / tetrahydrofuran / -5 - 5 °C 5.2: -5 - 5 °C 6.1: isopropyl alcohol / 60 °C View Scheme
参考文献
DR. REDDY'S LABORATORIES LTD.; DR. REDDY'S LABORATORIES, INC.; KATKAM, Srinivas; POLAVARAPU, Srinivas; YADDANAPUDI, Venkata Madhavi; VINIGARI, Krishna; PAGADALA, Narasimha Rao; SAGYAM, Rajeshwar Reddy
Patent: WO2011/159903 A2, 2011 ;
反应条件
1.1: thionyl chloride / N,N-dimethyl-formamide; toluene / 40 - 50 °C 1.2: 0 - 30 °C 2.1: potassium tert-butylate / toluene / 15 - 30 °C / Inert atmosphere 2.2: 0 - 5 °C / pH 2 - 2.5 3.1: phosphorus pentoxide; phosphoric acid / 100 - 120 °C View Scheme
参考文献
DR. REDDY'S LABORATORIES LTD.; DR. REDDY'S LABORATORIES, INC.; KATKAM, Srinivas; POLAVARAPU, Srinivas; YADDANAPUDI, Venkata Madhavi; VINIGARI, Krishna; PAGADALA, Narasimha Rao; SAGYAM, Rajeshwar Reddy
Patent: WO2011/159903 A2, 2011 ;
反应条件
1.1: thionyl chloride / N,N-dimethyl-formamide; toluene / 40 - 50 °C 1.2: 0 - 30 °C 2.1: potassium tert-butylate / toluene / 15 - 30 °C / Inert atmosphere 2.2: 0 - 5 °C / pH 2 - 2.5 3.1: phosphorus pentoxide; phosphoric acid / 100 - 120 °C 4.1: magnesium / methanol / 25 - 65 °C / Reflux 5.1: lithium aluminium tetrahydride; AlCl3, aluminium chloride / tetrahydrofuran / -5 - 5 °C 5.2: -5 - 5 °C View Scheme
参考文献
DR. REDDY'S LABORATORIES LTD.; DR. REDDY'S LABORATORIES, INC.; KATKAM, Srinivas; POLAVARAPU, Srinivas; YADDANAPUDI, Venkata Madhavi; VINIGARI, Krishna; PAGADALA, Narasimha Rao; SAGYAM, Rajeshwar Reddy
Patent: WO2011/159903 A2, 2011 ;
