1: With lithium chloride in isobutyramide T=80°C; 3 h; 2: With water in isobutyramide T=20°C; 1.83333 h;

1: 94.5 percent / periodic acid / methanol; H2O / 16 h / 20 °C 2: 1.) TEA, 2.) diisopropylamine / 1.) CH2Cl2, 0 deg C, 30 min, 2.) 20 deg C, 2 h. View Scheme

1: 94.5 percent / periodic acid / methanol; H2O / 16 h / 20 °C 2: 1.) TEA, 2.) diisopropylamine / 1.) CH2Cl2, 0 deg C, 30 min, 2.) 20 deg C, 2 h. 3: TEA / tetrahydrofuran / 0.5 h / 20 °C 4: tetrahydrofuran; dimethylformamide / 16 h / 20 °C View Scheme