6-氟-2-苯基-1H-吲哚合成路线 （共 12 条）
反应条件
copper(l) iodide; calcium carbonate in N,N-dimethyl-formamide T=120°C; 20 h;
参考文献
Rowley; Hallett; Goodacre; Moyes; Crawforth; Sparey; Patel; Marwood; Thomas; Hitzel; O'Connor; Szeto; Castro; Hutson; Macleod
Journal of Medicinal Chemistry, 2001 , vol. 44, # 10 p. 1603 - 1614
反应条件
dicyclohexyl(2′,6′-dimethoxybiphenyl-2-yl)phosphine; palladium diacetate; potassium phosphate in toluene T=90°C; Suzuki-Miyaura coupling; 2.5 h;
参考文献
Fang, Yuan-Qing; Lautens, Mark
Journal of Organic Chemistry, 2008 , vol. 73, # 2 p. 538 - 549
反应条件
sulfuric acid; silver(I) acetate; palladium dichloride in N,N-dimethyl-formamide; acetonitrile T=100°C; 0.666667 h; Sealed tubeMicrowave irradiation; regioselective reaction;
参考文献
Miao, Tao; Li, Pinhua; Wang, Guan-Wu; Wang, Lei
Chemistry - An Asian Journal, 2013 , vol. 8, # 12 p. 3185 - 3190
反应条件
1: 2-dimethylamino-2'-dicyclohexylphosphino-binaphthyl; potassium phosphate; phenol / Pd2(dba)3 / toluene / 15 h / 50 °C 2: 164 mg / titanium trichloride; ammonium acetate / ethanol; H2O / 0.25 h / 20 °C View Scheme
参考文献
Journal of the American Chemical Society, , vol. 124, # 51 p. 15168 - 15169
反应条件
1: 2-dimethylamino-2'-dicyclohexylphosphino-binaphthyl; potassium phosphate; phenol / Pd2(dba)3 / toluene / 15 h / 50 °C 2: 164 mg / titanium trichloride; ammonium acetate / ethanol; H2O / 0.25 h / 20 °C View Scheme
参考文献
Journal of the American Chemical Society, , vol. 124, # 51 p. 15168 - 15169
反应条件
CyPF-tBu; [Pd(η3-1-Ph-allyl)(μ-Cl)]2; potassium tert-butylate; ammonia in 1,4-dioxane T=90°C; 3 h; Inert atmosphere;
参考文献
Alsabeh, Pamela G.; Lundgren, Rylan J.; Longobardi, Lauren E.; Stradiotto, Mark
Chemical Communications, 2011 , vol. 47, # 24 p. 6936 - 6938
反应条件
silver(I) acetate in methanol T=90°C; Schlenk technique;
参考文献
Fang, Yan; Wang, Chengming; Su, Shengqin; Yu, Haizhu; Huang, Yong
Organic and Biomolecular Chemistry, 2014 , vol. 12, # 7 p. 1061 - 1071
反应条件
1: 80 percent / N-butylamine; CuI / Pd(PPh3)2Cl2 / 16 h / Heating 2: 95 percent / CuI; CaCO3 / dimethylformamide / 20 h / 120 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 44, # 10 p. 1603 - 1614
反应条件
indium; hydrogen iodide; Aliquatreg; 336 in benzene 12 h; Heating;
参考文献
Kim, Ji Sook; Han, Joon Hee; Lee, Jung June; Jun, Young Moo; Lee, Byung Min; Kim, Byeong Hyo
Tetrahedron Letters, 2008 , vol. 49, # 23 p. 3733 - 3738
反应条件
1: PPh3 / CH2Cl2 / 0 - 20 °C 2: 2.35 g / SnCl2*2H2O / ethanol / 0.75 h / Heating 3: 80 percent / K3PO4*H2O; Pd(OAc)2; S-Phos / toluene / 2.5 h / 90 °C View Scheme
参考文献
Organic Letters, , vol. 7, # 16 p. 3549 - 3552
