2-溴-4'-三氟甲基联苯合成路线 (共 3 条)
反应条件
sodium carbonate; tetrakis(triphenylphosphine) palladium(0) in ethylene glycol dimethyl ether; ethanol; water
参考文献
Buchwald, Stephen L.; Huang, Xiaohua; Zim, Danilo
Patent: US2004/171833 A1, 2004 ;
反应条件
1: 4-trifluoromethyl-1-iodobenzene With tert.-butyl lithium in tetrahydrofuran T=-78°C; 1 h; 2: With zinc dibromide in tetrahydrofuran T=20°C; 0.5 h; 3: 1-bromo-2-iodo-benzene With triphenylphosphine; [Pd(dibenzylideneacetone)2] in tetrahydrofuran T=20°C;
参考文献
Varela, Jesus A.; Pena, Diego; Goldfuss, Bernd; Denisenko, Dmitri; Kulhanek, Jiri; Polborn, Kurt; Knochel, Paul
Chemistry - A European Journal, 2004 , vol. 10, # 17 p. 4252 - 4264
反应条件
1: 4-trifluoromethylphenylbromobenzene With tert.-butyl lithium in tetrahydrofuran T=-78°C; 0.5 h; 2: N,N-dimethyl-formamide in tetrahydrofuran T=-78 - 20°C;
参考文献
Varela, Jesus A.; Pena, Diego; Goldfuss, Bernd; Denisenko, Dmitri; Kulhanek, Jiri; Polborn, Kurt; Knochel, Paul
Chemistry - A European Journal, 2004 , vol. 10, # 17 p. 4252 - 4264