1: 2-bromo-2'-methylbiphenyl With magnesium in tetrahydrofuran T=65°C; Grignard reaction; 4.5 h; 2: chlorodi-tert-butylphosphine With copper(l) chloride in tetrahydrofuran T=65°C; Substitution; 16 h; Further stages.;

1: 1-bromo-2-methyl benzene With magnesium in tetrahydrofuran T=60°C; Metallation; 2 h; 2: 1-bromo-2-chloro-benzene in tetrahydrofuran T=60°C; Arylation; 2 h; 3: chlorodi-tert-butylphosphine With copper(l) chloride in tetrahydrofuran T=60°C; Substitution; 12 h; Further stages.;

1.1: bis-triphenylphosphine-palladium(II) chloride; potassium carbonate / ethylene glycol dimethyl ether; water / 5 h / 80 °C / |Inert atmosphere 2.1: n-butyllithium / diethyl ether; hexane / 2 h / 0 °C / |Inert atmosphere 2.2: 1 h / 20 °C / |Inert atmosphere View Scheme

1.1: bis-triphenylphosphine-palladium(II) chloride; potassium carbonate / ethylene glycol dimethyl ether; water / 5 h / 80 °C / |Inert atmosphere 2.1: n-butyllithium / diethyl ether; hexane / 2 h / 0 °C / |Inert atmosphere 2.2: 1 h / 20 °C / |Inert atmosphere View Scheme