N-Boc-2-氮杂环丁基甲酸甲酯合成路线 （共 7 条）
反应条件
1: N-(tert-Butoxycarbonyl)-(S)-(-)-2-azetidinecarboxylic acid With 4-methyl-morpholine; isobutyl chloroformate in tetrahydrofuran T=-10 - 25°C; 4 h; 2: methanol in tetrahydrofuran T=18 - 25°C; 18 h;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2006/100461 A1, 2006 ;
Location in patent: Page/Page column 79 ;
WO 2006/100461 A1
反应条件
triethylamine in dichloromethane
参考文献
Merck and Co., Inc.
Patent: US6645939 B1, 2003 ;
反应条件
palladium on activated charcoal in methanol T=20°C;
参考文献
Baktharaman, Sivaraj; Selvakumar, Sermadurai; Singh, Vinod K.
Organic Letters, 2006 , vol. 8, # 19 p. 4335 - 4338
反应条件
4-(N,N-dimethlyamino)pyridine in acetonitrile T=0 - 20°C; 24 h;
参考文献
US2003/229226 A1, ;
Page 19 ;
反应条件
NMM in tetrahydrofuran; methanol
参考文献
US5409946 A1, ;
US 5409946 A
反应条件
1: With sodium tetrahydroborate in tetrahydrofuran Heating / reflux; 2: With methanol in tetrahydrofuran 1.5 h; Heating / reflux;
参考文献
Okamoto, Osamu; Falgueyret, Jean-Pierre; Oballa, Renata Marcella; Prasit, Petpiboon; Rydzewski, Robert
Patent: US2003/229226 A1, 2003 ;
Location in patent: Page 19 ;
反应条件
lithium hydroxide hydrate in 1,4-dioxane; water T=20°C; 2.5 h;
参考文献
ZAFGEN CORPORATION; DYKE, Hazel, Joan; CRAMP, Susan, Mary; PALLIN, Thomas, David; KULAGOWSKI, Janusz, Jozef; MONTANA, John, Gary; ZAHLER, Robert
Patent: WO2011/44506 A2, 2011 ;
Location in patent: Page/Page column 211 ;
WO 2011/044506 A1
