1-(3,4-二氟苯基)哌嗪合成路线 （共 6 条）
反应条件
hydrogenchloride; hydrogen; palladium on activated charcoal in ethanol T=20°C; 64.5 h; atmospheric pressure;
参考文献
Baenziger, Markus; Cercus, Jacques; Hirt, Hans; Laumen, Kurt; Malan, Christophe; Spindler, Felix; Struber, Fritz; Troxler, Thomas
Tetrahedron Asymmetry, 2003 , vol. 14, # 22 p. 3469 - 3477
反应条件
sodium carbonate; sodium sulfate in nBuOH; butan-1-ol
参考文献
US2004/162282 A1, ;
US 20040162282 A1
反应条件
potassium carbonate in 1-methyl-pyrrolidin-2-one T=220°C; 2 h; Microwave irradiationSealed tube; Overall yield = 92 percent;
参考文献
Journal of Fluorine Chemistry, , vol. 146, p. 70 - 75
反应条件
sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium(0); 2,2'-bis-(diphenylphosphino)-1,1'- binaphthyl in toluene Heating / reflux;
参考文献
BAYER HEALTHCARE AG
Patent: WO2004/96778 A1, 2004 ;
Location in patent: Page/Page column 31 ;
反应条件
Buchwald-Hartwig amination;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 17, # 5 p. 1376 - 1380
反应条件
1.1: carbonyldiimidazole / toluene / 2 h / 20 °C 1.2: triethylamine / toluene / 112 h / 20 °C 2.1: trifluoroacteic acid / toluene / 3 h / 20 °C View Scheme
参考文献
Baenziger, Markus; Cercus, Jacques; Hirt, Hans; Laumen, Kurt; Malan, Christophe; Spindler, Felix; Struber, Fritz; Troxler, Thomas
Tetrahedron Asymmetry, 2003 , vol. 14, # 22 p. 3469 - 3477
