4,4,4-三氟巴豆酸乙酯合成路线 （共 32 条）
反应条件
sodium tetrahydroborate in ethylene glycol dimethyl ether var. solv.: DG, THF;
参考文献
Dedek, Vaclav; Liska, Frantisek; Fikar, Jiri; Barta, Milan; Kasparova, Marie; et. al
Journal of Fluorine Chemistry, 1985 , vol. 29, p. 151
反应条件
(i) H2, PtO2, Et2O, (ii) LiAlH4; Multistep reaction;
参考文献
Pegolotti,J.A.; Young,W.G.
Journal of the American Chemical Society, 1961 , vol. 83, p. 3258 - 3262
反应条件
potassium carbonate in DMF (N,N-dimethyl-formamide) T=60°C; 20 h;
参考文献
PHARMACIA CORPORATION
Patent: WO2004/87686 A2, 2004 ;
Location in patent: Page 244-245 ;
Title/Abstract Full Text Show Details
PHARMACIA CORPORATION
Patent: WO2004/87687 A1, 2004 ;
Location in patent: Page 244-245 ;
WO 2004/087687 A1
反应条件
in methanol; water; N,N-dimethyl-formamide
参考文献
G.D. Searle and Co.
Patent: US6077850 A1, 2000 ;
反应条件
lithium aluminium tetrahydride; aluminium trichloride in diethyl ether T=0°C; 0.5 h;
参考文献
Ishikawa, Nobuo; Koh, Moon Gyu; Kitazume, Tomoya; Choi, Sam Kwon
Journal of Fluorine Chemistry, 1984 , vol. 24, p. 419 - 430
反应条件
lithium aluminium tetrahydride; aluminium trichloride in diethyl ether T=0°C; 0.5 h;
参考文献
Ishikawa, Nobuo; Koh, Moon Gyu; Kitazume, Tomoya; Choi, Sam Kwon
Journal of Fluorine Chemistry, 1984 , vol. 24, p. 419 - 430
反应条件
sodium hydroxide in tetrahydrofuran
参考文献
Tamura, Kenji; Yamazaki, Takashi; Kitazume, Tomoya; Kubota, Toshio
Journal of Fluorine Chemistry, 2005 , vol. 126, # 6 p. 918 - 930
反应条件
diethyl ether; ammonia
参考文献
Walborsky; Schwarz
Journal of the American Chemical Society, 1953 , vol. 75, p. 3241
参考文献
Walter, Harald
Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences, 2008 , vol. 63, # 4 p. 351 - 362
反应条件
Sodium hydride in diethyl ether; dimethyl sulfoxide T=5 - 10°C; 1 h;
参考文献
Syngenta Crop Protection, Inc.
Patent: US6365620 B2, 2002 ;
Location in patent: Example P 1 ;
