4,4,4-三氟巴豆酸乙酯合成路线 （共 32 条）
反应条件
N,N,N',N'-tetramethylguanidine T=20°C; 13 h;
参考文献
F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; BROTHERTON-PLEISS, Christine E.; ERICKSON, Shawn David; LI, Hongju; SO, Sung-Sau
Patent: WO2014/72325 A1, 2014 ;
Location in patent: Paragraph 0074 ;
反应条件
lithium diisopropyl amide in tetrahydrofuran; hexane 1.) -78 deg C, 30 min, 2.) -78 deg C, 1.5 h;
参考文献
Shinohara, Noriyasu; Haga, Jiro; Yamazaki, Takashi; Kitazume, Tomoya; Nakamura, Shinichiro
Journal of Organic Chemistry, 1995 , vol. 60, # 14 p. 4363 - 4374
反应条件
1: ethyl acetoacetate With ethanol; sodium T=20°C; 0.666667 h; 2: 4,4,4-trifluoro-2-butenoic acid ethyl ester in ethanol 14 h; Heating;
参考文献
Okoro, Cosmas O.; Fadeyi, Olugbeminiyi O.; Jackson, Patrice L.; Richmond, Rhonda L.; Farmer, Takeisha
Tetrahedron Letters, 2006 , vol. 47, # 42 p. 7451 - 7454
反应条件
1: With sodium ethanolate in ethanol 7 h; Heating; 2: With sodium hydroxide in water 1 h; Heating; Further stages.;
参考文献
Fadeyi, Olugbeminiyi O.; Okoro, Cosmas O.
Tetrahedron Letters, 2008 , vol. 49, # 32 p. 4725 - 4727
反应条件
sodium methylate in methanol 7 h; Heating;
参考文献
Fadeyi, Olugbeminiyi O.; Okoro, Cosmas O.
Tetrahedron Letters, 2008 , vol. 49, # 32 p. 4725 - 4727
反应条件
1: With sodium ethanolate in ethanol 7 h; Heating; 2: With sodium hydroxide in water 1 h; Heating; Further stages.;
参考文献
Fadeyi, Olugbeminiyi O.; Okoro, Cosmas O.
Tetrahedron Letters, 2008 , vol. 49, # 32 p. 4725 - 4727
反应条件
ethyl bromide; hydrogen bromide
参考文献
Walborsky; Schwarz
Journal of the American Chemical Society, 1953 , vol. 75, p. 3241
参考文献
Walborsky; Schwarz
Journal of the American Chemical Society, 1953 , vol. 75, p. 3241
参考文献
Walborsky; Schwarz
Journal of the American Chemical Society, 1953 , vol. 75, p. 3241
参考文献
Walborsky; Schwarz
Journal of the American Chemical Society, 1953 , vol. 75, p. 3241
