1-(2-氟苄基)-1H-吡唑并[3,4-b]吡啶-3-甲腈合成路线 （共 11 条）
反应条件
pyridine; trifluoroacetic anhydride T=20°C; 8 h;
参考文献
BAYER HEALTHCARE AG
Patent: WO2004/9589 A1, 2004 ;
Location in patent: Page/Page column 30 ;
反应条件
1: 1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboxamide With pyridine in tetrahydrofuran 0.166667 h; 2: trifluoroacetic anhydride T=20 - 40°C;
参考文献
Bayer HealthCare AG
Patent: US6833364 B1, 2004 ;
Location in patent: Page column 33 ;
反应条件
caesium carbonate in N,N-dimethyl-formamide 16 h; regioselective reaction;
参考文献
Griebenow, Nils; Schirok, Hartmut; Mittendorf, Joachim; Straub, Alexander; Follmann, Markus; Stasch, Johannes-Peter; Knorr, Andreas; Schlemmer, Karl-Heinz; Redlich, Gorden
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 5 p. 1197 - 1200
反应条件
1: TFA / dioxane / 8 h / Heating 2: TFA / dioxane / 72 h / Heating 3: 100 percent / NH3 / methanol / 48 h / 20 °C 4: 100 percent / TFAA / pyridine / 8 h View Scheme
参考文献
Straub, Alexander; Stasch, Johannes-Peter; Alonso-Alija, Cristina; Benet-Buchholz, Jordi; Ducke, Bernhard; Feurer, Achim; Fuerstner, Chantal
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 6 p. 781 - 784
反应条件
1: TFA / dioxane / 72 h / Heating 2: 100 percent / NH3 / methanol / 48 h / 20 °C 3: 100 percent / TFAA / pyridine / 8 h View Scheme
参考文献
Straub, Alexander; Stasch, Johannes-Peter; Alonso-Alija, Cristina; Benet-Buchholz, Jordi; Ducke, Bernhard; Feurer, Achim; Fuerstner, Chantal
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 6 p. 781 - 784
反应条件
1: 100 percent / NH3 / methanol / 48 h / 20 °C 2: 100 percent / TFAA / pyridine / 8 h View Scheme
参考文献
Straub, Alexander; Stasch, Johannes-Peter; Alonso-Alija, Cristina; Benet-Buchholz, Jordi; Ducke, Bernhard; Feurer, Achim; Fuerstner, Chantal
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 6 p. 781 - 784
反应条件
1: lithium diisopropyl amide / tetrahydrofuran / 4 h / -75 °C 2: hydrazine hydrate / 6 h / 70 °C 3: ammonia / water / 0.2 h / 140 °C 4: caesium carbonate / N,N-dimethyl-formamide / 16 h View Scheme
参考文献
Griebenow, Nils; Schirok, Hartmut; Mittendorf, Joachim; Straub, Alexander; Follmann, Markus; Stasch, Johannes-Peter; Knorr, Andreas; Schlemmer, Karl-Heinz; Redlich, Gorden
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 5 p. 1197 - 1200
反应条件
1: ammonia / water / 0.2 h / 140 °C 2: caesium carbonate / N,N-dimethyl-formamide / 16 h View Scheme
参考文献
Griebenow, Nils; Schirok, Hartmut; Mittendorf, Joachim; Straub, Alexander; Follmann, Markus; Stasch, Johannes-Peter; Knorr, Andreas; Schlemmer, Karl-Heinz; Redlich, Gorden
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 5 p. 1197 - 1200
反应条件
1: hydrazine hydrate / 6 h / 70 °C 2: ammonia / water / 0.2 h / 140 °C 3: caesium carbonate / N,N-dimethyl-formamide / 16 h View Scheme
参考文献
Griebenow, Nils; Schirok, Hartmut; Mittendorf, Joachim; Straub, Alexander; Follmann, Markus; Stasch, Johannes-Peter; Knorr, Andreas; Schlemmer, Karl-Heinz; Redlich, Gorden
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 5 p. 1197 - 1200
反应条件
1: With sodium methylate in methanol T=20°C; 2 h; 2: With ammonium chloride; acetic acid in methanol Heating / reflux;
参考文献
BAYER HEALTHCARE AG
Patent: WO2004/9590 A1, 2004 ;
Location in patent: Page/Page column 23 ;
