-[(2-氟苯基甲基]-1H-吡唑并[3,4-b]吡啶-3-甲脒合成路线 （共 10 条）
反应条件
ammonium chloride; acetic acid in methanol 8 h; Heating;
参考文献
Bayer HealthCare AG
Patent: US6833364 B1, 2004 ;
Location in patent: Page column 34 ;
反应条件
1: With sodium methylate in methanol T=20°C; 2 h; 2: With ammonium chloride; acetic acid in methanol Heating / reflux;
参考文献
BAYER HEALTHCARE AG
Patent: WO2004/9590 A1, 2004 ;
Location in patent: Page/Page column 23 ;
反应条件
1.1: TFA / dioxane / 8 h / Heating 2.1: TFA / dioxane / 72 h / Heating 3.1: 100 percent / NH3 / methanol / 48 h / 20 °C 4.1: 100 percent / TFAA / pyridine / 8 h 5.1: 100 percent / methanol / 2 h / 20 °C 6.1: NH4Cl; HOAc / methanol / 8 h / Heating 6.2: 76 percent / Na2CO3 / H2O / 20 °C View Scheme
参考文献
Straub, Alexander; Stasch, Johannes-Peter; Alonso-Alija, Cristina; Benet-Buchholz, Jordi; Ducke, Bernhard; Feurer, Achim; Fuerstner, Chantal
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 6 p. 781 - 784
反应条件
1.1: TFA / dioxane / 72 h / Heating 2.1: 100 percent / NH3 / methanol / 48 h / 20 °C 3.1: 100 percent / TFAA / pyridine / 8 h 4.1: 100 percent / methanol / 2 h / 20 °C 5.1: NH4Cl; HOAc / methanol / 8 h / Heating 5.2: 76 percent / Na2CO3 / H2O / 20 °C View Scheme
参考文献
Straub, Alexander; Stasch, Johannes-Peter; Alonso-Alija, Cristina; Benet-Buchholz, Jordi; Ducke, Bernhard; Feurer, Achim; Fuerstner, Chantal
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 6 p. 781 - 784
反应条件
1.1: 100 percent / TFAA / pyridine / 8 h 2.1: 100 percent / methanol / 2 h / 20 °C 3.1: NH4Cl; HOAc / methanol / 8 h / Heating 3.2: 76 percent / Na2CO3 / H2O / 20 °C View Scheme
参考文献
Straub, Alexander; Stasch, Johannes-Peter; Alonso-Alija, Cristina; Benet-Buchholz, Jordi; Ducke, Bernhard; Feurer, Achim; Fuerstner, Chantal
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 6 p. 781 - 784
反应条件
1.1: 100 percent / NH3 / methanol / 48 h / 20 °C 2.1: 100 percent / TFAA / pyridine / 8 h 3.1: 100 percent / methanol / 2 h / 20 °C 4.1: NH4Cl; HOAc / methanol / 8 h / Heating 4.2: 76 percent / Na2CO3 / H2O / 20 °C View Scheme
参考文献
Straub, Alexander; Stasch, Johannes-Peter; Alonso-Alija, Cristina; Benet-Buchholz, Jordi; Ducke, Bernhard; Feurer, Achim; Fuerstner, Chantal
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 6 p. 781 - 784
参考文献
Bayer HealthCare AG
Patent: US6833364 B1, 2004 ;
Location in patent: Page column 37,38 ;
参考文献
Bayer HealthCare AG
Patent: US6833364 B1, 2004 ;
Location in patent: Page column 37 ;
反应条件
in toluene 8 h; Heating;
参考文献
Straub, Alexander; Stasch, Johannes-Peter; Alonso-Alija, Cristina; Benet-Buchholz, Jordi; Ducke, Bernhard; Feurer, Achim; Fuerstner, Chantal
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 6 p. 781 - 784
参考文献
Stasch, Johannes-Peter; Feurer, Achim; Weigand, Stefan; Stahl, Elke; Flubacher, Dietmar; Alonso-Alija, Cristina; Wunder, Frank; Lang, Dieter; Dembowsky, Klaus; Straub, Alexander; Perzborn, Elisabeth
Patent: US2002/173514 A1, 2002 ;
