1: With n-butyllithium; tri-isopropoxy-borane in tetrahydrofuran; hexane T=-78 - 20°C; 16 h; 2: With hydrogenchloride in tetrahydrofuran; hexane; water T=20°C; 1 h;

1: With potassium hydrogen fluoride in methanol; water 0.5 h; 2: With chloro-trimethyl-silane; water in acetonitrile 1 h;

1.1: dicyclohexyl(2′,6′-dimethoxybiphenyl-2-yl)phosphine; tripotassium phosphate monohydrate; palladium diacetate / toluene 2.1: 10 palladium on activated charcoal; hydrogen / ethanol 3.1: hydrogenchloride; sodium nitrite / water / Cooling with ice 4.1: dicyclohexyl(2′,6′-dimethoxybiphenyl-2-yl)phosphine; palladium diacetate; triethylamine / 1,4-dioxane / 80 °C 5.1: potassium hydrogen fluoride / methanol; water / 0.5 h 5.2: 1 h View Scheme

1.1: dicyclohexyl(2′,6′-dimethoxybiphenyl-2-yl)phosphine; tripotassium phosphate monohydrate; palladium diacetate / toluene 2.1: 10 palladium on activated charcoal; hydrogen / ethanol 3.1: hydrogenchloride; sodium nitrite / water / Cooling with ice 4.1: dicyclohexyl(2′,6′-dimethoxybiphenyl-2-yl)phosphine; palladium diacetate; triethylamine / 1,4-dioxane / 80 °C 5.1: potassium hydrogen fluoride / methanol; water / 0.5 h 5.2: 1 h View Scheme

1.1: hydrogenchloride; sodium nitrite / water / Cooling with ice 2.1: dicyclohexyl(2′,6′-dimethoxybiphenyl-2-yl)phosphine; palladium diacetate; triethylamine / 1,4-dioxane / 80 °C 3.1: potassium hydrogen fluoride / methanol; water / 0.5 h 3.2: 1 h View Scheme

1.1: dicyclohexyl(2′,6′-dimethoxybiphenyl-2-yl)phosphine; palladium diacetate; triethylamine / 1,4-dioxane / 80 °C 2.1: potassium hydrogen fluoride / methanol; water / 0.5 h 2.2: 1 h View Scheme

1.1: 10 palladium on activated charcoal; hydrogen / ethanol 2.1: hydrogenchloride; sodium nitrite / water / Cooling with ice 3.1: dicyclohexyl(2′,6′-dimethoxybiphenyl-2-yl)phosphine; palladium diacetate; triethylamine / 1,4-dioxane / 80 °C 4.1: potassium hydrogen fluoride / methanol; water / 0.5 h 4.2: 1 h View Scheme