C60H84N12Pd4S8 in tetrahydrofuran Negishi coupling reaction; Inert atmosphere;

1: With acetone O-(2,4,6-trimethylphenylsulfonyl)oxime in tetrahydrofuran T=20°C; Amination; 3 h; 2: With hydrogenchloride; water T=20°C; Hydrolysis; 2 h;

C15H24ClN3PdS2(1+)*Cl(1-) in tetrahydrofuran T=25 - 40°C; Negishi coupling reaction; Inert atmosphere;

1: CyZnCl With tetrabutylammomium bromide; palladium diacetate in tetrahydrofuran T=20°C; Negishi coupling reaction; 0.0833333 h; Inert atmosphere; 2: benzoyl chloride in tetrahydrofuran T=20°C; Negishi coupling reaction; 1 h; Inert atmosphere;

1.1: CuCN; acetone O-(2,4,6-trimethylphenylsulfonyl)oxime / tetrahydrofuran / 3 h / 20 °C 1.2: 12 percent / HCl; water / 2 h / 20 °C 2.1: NaOH View Scheme

C15H24ClN3PdS2(1+)*Cl(1-) in tetrahydrofuran T=25 - 40°C; Negishi coupling reaction; Inert atmosphere;