1-Boc-4-(氰基甲基)哌啶合成路线 （共 11 条）
反应条件
pyridine; trifluoroacetic anhydride in tetrahydrofuran T=0 - 20°C; 5 h;
参考文献
WO2004/92124 A2, ;
Page 91 ;
WO 2004/092124 A2
反应条件
O-(diphenyl-phosphinyl)hydroxylamine in toluene T=20 - 85°C; chemoselective reaction;
参考文献
Laulhe, Sebastien; Gori, Sadakatali S.; Nantz, Michael H.
Journal of Organic Chemistry, 2012 , vol. 77, # 20 p. 9334 - 9337,4
Title/Abstract Full Text Show Details
Laulhe, Sebastien; Gori, Sadakatali S.; Nantz, Michael H.
Journal of Organic Chemistry, 2012 , vol. 77, # 20 p. 9334 - 9337
反应条件
1: N-tert-butyloxycarbonyl-4-hydroxymethylpiperidine With methanesulfonyl chloride; triethylamine in acetonitrile 2: potassium cyanide in ethanol Heating / reflux;
参考文献
US2005/107434 A1, ;
Page/Page column 17 ;
US 20050107434 A1
反应条件
in ethanol; water T=80°C; 24 h;
参考文献
KOWA CO., LTD.; Morimoto, Toshiharu; Koshizawa, Tomoaki; Watanabe, Gen; Ohgiya, Tadaaki; Yamasaki, Nao; Inoue, Noriyuki
Patent: US2013/102621 A1, 2013 ;
Location in patent: Paragraph 0281; 0282 ;
反应条件
in ethanol 12 h; Heating / reflux;
参考文献
WO2004/54973 A2, ;
Page 38 ;
WO 2004/054973 A2
反应条件
1: lithium hexamethyldisilazane / tetrahydrofuran / 0.67 h / -70 °C / Inert atmosphere 2: hydrogen / palladium 10 on activated carbon / ethyl acetate / 3.5 h / 20 °C View Scheme
反应条件
1.1: sodium hydroxide / water / 0 °C 1.2: 4 h 2.1: potassium carbonate / tetrahydrofuran / 12 h / Reflux 3.1: hydrogen / palladium on activated charcoal / ethanol / 8 h View Scheme
参考文献
WO2011/104680 A1, ;
WO 2011/104680 A1
反应条件
1.1: sodium hydroxide / water / 0 °C 1.2: 4 h 2.1: potassium carbonate / tetrahydrofuran / 12 h / Reflux 3.1: hydrogen / palladium on activated charcoal / ethanol / 8 h View Scheme
参考文献
WO2011/104680 A1, ;
WO 2011/104680 A1
反应条件
1: sodium hydrogencarbonate / tetrahydrofuran; water / 20 °C 2: triethylamine / tetrahydrofuran; water / 0.67 h / |Inert atmosphere; |Cooling with ice 3: water; ethanol / 24 h / 80 °C View Scheme
反应条件
1: sodium hydrogencarbonate / tetrahydrofuran; water / 20 °C 2: triethylamine / tetrahydrofuran; water / 0.67 h / |Inert atmosphere; |Cooling with ice 3: water; ethanol / 24 h / 80 °C View Scheme
