(E)-3-[2-环丙基-4-(4-氟苯基)-3-喹啉基]-2-丙烯腈合成路线 （共 9 条）
反应条件
sodium hydroxide; Aliquatreg; 336 in toluene T=20°C; Emmons-Horner coupling; 2 h;
参考文献
Suzuki; Iwasaki; Fujikawa; Kitahara; Sakashita; Sakoda
Bioorganic and Medicinal Chemistry, 2001 , vol. 9, # 10 p. 2727 - 2743
反应条件
1.1: n-butyllithium / tetrahydrofuran; hexane / -78 °C 1.2: tetrahydrofuran; hexane / -78 °C 2.1: 85.1 percent / aq. NaOH; trioctylmethylammonium chloride / toluene / 2 h / 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 9, # 10 p. 2727 - 2743
反应条件
1.1: pyridinium chlorochromate; sodium acetate / CH2Cl2 / 20 °C 2.1: n-butyllithium / tetrahydrofuran; hexane / -78 °C 2.2: tetrahydrofuran; hexane / -78 °C 3.1: 85.1 percent / aq. NaOH; trioctylmethylammonium chloride / toluene / 2 h / 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 9, # 10 p. 2727 - 2743
反应条件
1: DMSO; P2O5; Et3N 2: NaOH; (n-octyl)3MeNCl / toluene; H2O View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 9, # 20 p. 2977 - 2982
反应条件
sodium hydroxide; Aliquatreg; 336 in water; toluene Condensation; Emmons-Horner reaction;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 9, # 20 p. 2977 - 2982
反应条件
1.1: DIBAH 2.1: NaH; n-BuLi 3.1: NaBH4; Et2BOMe / -78 °C 4.1: aq. NaOH 4.2: (+)-α-methylbenzylamine View Scheme
参考文献
Suzuki, Mikio; Yanagawa, Yoshinobu; Iwasaki, Hiroshi; Kanda, Hiroyasu; Yanagihara, Kazufumi; Matsumoto, Hiroo; Ohara, Yoshio; Yazaki, Yukari; Sakoda, Ryozo
Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 20 p. 2977 - 2982
反应条件
1: 86.5 percent / diisobutylaluminum hydride / toluene / 1 h / -15 °C 2: 83.5 percent / NaH; n-BuLi / tetrahydrofuran; hexane / 3 h / -10 °C View Scheme
参考文献
Suzuki, Mikio; Yanagawa, Yoshinobu; Iwasaki, Hiroshi; Kanda, Hiroyasu; Yanagihara, Kazufumi; Matsumoto, Hiroo; Ohara, Yoshio; Yazaki, Yukari; Sakoda, Ryozo
Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 20 p. 2977 - 2982
反应条件
diisobutylaluminium hydride in toluene T=-15°C; 1 h;
参考文献
Suzuki; Iwasaki; Fujikawa; Kitahara; Sakashita; Sakoda
Bioorganic and Medicinal Chemistry, 2001 , vol. 9, # 10 p. 2727 - 2743
反应条件
1.1: DIBAH
2.1: NaH; n-BuLi
3.1: NaBH4; Et2BOMe / -78 °C
4.1: aq. NaOH
4.2: (-)-α-methylbenzylamine
View Scheme
参考文献
Suzuki, Mikio; Yanagawa, Yoshinobu; Iwasaki, Hiroshi; Kanda, Hiroyasu; Yanagihara, Kazufumi; Matsumoto, Hiroo; Ohara, Yoshio; Yazaki, Yukari; Sakoda, Ryozo
Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 20 p. 2977 - 2982
