2-(膦氧基)丙烷-1,2,3-三羧酸合成路线 （共 12 条）
反应条件
1: PCl5 / benzene / 0.5 h / 5 °C
2: H2O / 0.5 h
3: H2 / Pd/C
View Scheme
参考文献
Pankowski, Andrew H.; Meehan, John D.; Sallis, John D.
Tetrahedron Letters, 1994 , vol. 35, # 6 p. 927 - 930
反应条件
1: 100 percent Spectr. / Et3N / diethyl ether / 24 h / 20 °C
2: Et3N / diethyl ether / 20 °C
3: SO2Cl2 / diethyl ether / 1 h / 20 °C
4: HCl / 20 h / 38 - 40 °C
View Scheme
参考文献
Turhanen, Petri A.; Demadis, Konstantinos D.; Peraeniemi, Sirpa; Vepsaelaeinen, Jouko J.
Journal of Organic Chemistry, 2007 , vol. 72, # 4 p. 1468 - 1471
反应条件
sodium hydroxide
Hydrogenation;
参考文献
Meyer et al.
Journal of the American Chemical Society, 1959 , vol. 81, p. 2094
反应条件
1: platinum; ethanol / Hydrogenation
2: aq. NaOH solution / Hydrogenation
View Scheme
参考文献
Meyer et al.
Journal of the American Chemical Society, 1959 , vol. 81, p. 2094
反应条件
1: Et3N / diethyl ether / 20 °C
2: SO2Cl2 / diethyl ether / 1 h / 20 °C
3: HCl / 20 h / 38 - 40 °C
View Scheme
参考文献
Turhanen, Petri A.; Demadis, Konstantinos D.; Peraeniemi, Sirpa; Vepsaelaeinen, Jouko J.
Journal of Organic Chemistry, 2007 , vol. 72, # 4 p. 1468 - 1471
反应条件
hydrogen; palladium on activated charcoal
Yield given;
参考文献
Pankowski, Andrew H.; Meehan, John D.; Sallis, John D.
Tetrahedron Letters, 1994 , vol. 35, # 6 p. 927 - 930
反应条件
hydrogenchloride
T=38 - 40°C; 20 h; Title compound not separated from byproducts;
参考文献
Turhanen, Petri A.; Demadis, Konstantinos D.; Peraeniemi, Sirpa; Vepsaelaeinen, Jouko J.
Journal of Organic Chemistry, 2007 , vol. 72, # 4 p. 1468 - 1471
反应条件
1: H2O / 0.5 h
2: H2 / Pd/C
View Scheme
参考文献
Pankowski, Andrew H.; Meehan, John D.; Sallis, John D.
Tetrahedron Letters, 1994 , vol. 35, # 6 p. 927 - 930
反应条件
0.166667 h; pseudo-cholinesterase;
参考文献
Sallis, John; Meehan, John; Kamperman, Harold; Anderson, Maree
Phosphorus, Sulfur and Silicon and the Related Elements, 1993 , vol. 76, # 1-4 p. 281 - 284
反应条件
0.166667 h; pseudo-cholinesterase;
参考文献
Sallis, John; Meehan, John; Kamperman, Harold; Anderson, Maree
Phosphorus, Sulfur and Silicon and the Related Elements, 1993 , vol. 76, # 1-4 p. 281 - 284
