5-氨基-1-[(2-氟苯基)甲基]-1H-吡唑-3-羧酸乙酯合成路线 （共 12 条）
反应条件
1: TFA / dioxane / 72 h / Heating 2: 100 percent / NH3 / methanol / 48 h / 20 °C 3: 100 percent / TFAA / pyridine / 8 h View Scheme
参考文献
Straub, Alexander; Stasch, Johannes-Peter; Alonso-Alija, Cristina; Benet-Buchholz, Jordi; Ducke, Bernhard; Feurer, Achim; Fuerstner, Chantal
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 6 p. 781 - 784
反应条件
1: TFA / dioxane / 72 h / Heating 2: 100 percent / NH3 / methanol / 48 h / 20 °C 3: 100 percent / TFAA; pyridine / 8 h / 20 °C 4: 100 percent / MeONa / 2 h / 20 °C 5: 76.4 percent / NH4Cl; HOAc / methanol / 8 h / Heating 6: 31.8 percent / toluene / 8 h / Heating View Scheme
参考文献
Straub, Alexander; Stasch, Johannes-Peter; Alonso-Alija, Cristina; Benet-Buchholz, Jordi; Ducke, Bernhard; Feurer, Achim; Fuerstner, Chantal
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 6 p. 781 - 784
