N-苄氧羰基-甘氨酰-甘氨酸合成路线 （共 69 条）
参考文献
Iselin et al.
Helvetica Chimica Acta, 1957 , vol. 40, p. 373,385
参考文献
Sakakibara,S.; Inukai,N.
Bulletin of the Chemical Society of Japan, 1964 , vol. 37, p. 1231 - 1232
反应条件
benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine in N,N-dimethyl-formamide T=20°C;
参考文献
Miyazawa, Toshifumi; Ensatsu, Eiichi; Hiramatsu, Makoto; Yanagihara, Ryoji; Yamada, Takashi
Journal of the Chemical Society. Perkin Transactions 1, 2002 , # 3 p. 396 - 401
参考文献
Bergmann; Zervas; Fruton
Journal of Biological Chemistry, 1935 , vol. 111, p. 225,243
Journal of Biological Chemistry, 1936 , vol. 115, p. 593,596, 599
反应条件
1: Et3N
2: triethylamine
View Scheme
参考文献
Horwell; Beeby; Clark; Hughes
Journal of Medicinal Chemistry, 1987 , vol. 30, # 4 p. 729 - 732
反应条件
triethylamine; dicyclohexyl-carbodiimide in N,N-dimethyl-formamide
12 h; Ambient temperature;
参考文献
Kanaoka; Takahashi; Nakayama; Tanizawa
Chemical and Pharmaceutical Bulletin, 1985 , vol. 33, # 4 p. 1721 - 1724
反应条件
1: pyridine
2: aqueous NaOH
3: isocyanatoacetic acid ethyl ester; toluene
View Scheme
参考文献
Goldschmidt; Wick
Justus Liebigs Annalen der Chemie, 1952 , vol. 575, p. 217,230
反应条件
dicyclohexyl-carbodiimide in methanol
参考文献
Schwyzer,R.; Tun-kyi,A.
Helvetica Chimica Acta, 1962 , vol. 45, p. 859 - 868
反应条件
1: 1.) N-hydroxybenzotriazole (HOBt), N,N'-dicyclohexylcarbodiimide (DCC), 2.) Et3N / 1.) DMF, 0 deg C, 1 h, 2.) DMF, from 0 deg C, 1 h to RT, overnight
2: 100 percent / 1N aq. NaOH / methanol / 1 h / Ambient temperature
View Scheme
参考文献
Morier-Teissier; Boitte; Helbecque; Bernier; Pommery; Duvalet; Fournier; Hecquet; Catteau; Henichart
Journal of Medicinal Chemistry, 1993 , vol. 36, # 15 p. 2084 - 2090
