N-苯甲酰-L-苯基丙氨酸合成路线 （共 71 条）
反应条件
1.1: Ac2O / 1 h / 95 °C 2.1: 121 g / pyridine / H2O / 12 h / 20 °C 3.1: aq. NaOH / dioxane / 1 h / 20 °C 3.2: cinchonidine / ethanol / 6 h 3.3: aq. HCl / 0.5 h 4.1: 90 percent / pyridine / 72 h / 5 °C 5.1: 72.4 percent / NaI; Zn / dimethylformamide / 10 h / 120 °C 6.1: 80.3 percent / HCl / 10 h / Heating View Scheme
参考文献
Shiraiwa, Tadashi; Suzuki, Masahiro; Sakai, Yoshio; Nagasawa, Hisashi; Takatani, Kazuhiro; Noshi, Daisuke; Yamanashi, Kenji
Chemical and pharmaceutical bulletin, 2002 , vol. 50, # 10 p. 1362 - 1366
反应条件
1: DCC / tetrahydrofuran / 2 h / Ambient temperature 2: triethylamine / dioxane / 1 h 3: Dichlorodicyano-p-benzoquinone (DDQ), disilylacetamide / dioxane / 1 h View Scheme
参考文献
Lott, Richard S.; Breitholle, Edward G.; Stammer, Charles H.
Journal of Organic Chemistry, 1980 , vol. 45, # 6 p. 1151 - 1153
反应条件
tri-cyclo-hexyl-phosphine; [RhCl(η2:η2-cycloocta-1,5-diene)]2 in acetonitrile T=60°C; Racemization; 48 h;
参考文献
Hateley, Martin J.; Schichl, Daniel A.; Kreuzfeld, Hans-Joern; Beller, Matthias
Tetrahedron Letters, 2000 , vol. 41, # 20 p. 3821 - 3824
反应条件
acetic acid in dichloromethane T=0°C; RefluxInert atmosphere;
参考文献
Metrano, Anthony J.; Miller, Scott J.
Journal of Organic Chemistry, 2014 , vol. 79, # 4 p. 1542 - 1554
反应条件
dicyclohexyl-carbodiimide
参考文献
Levi,I. et al.
Journal of Medicinal Chemistry, 1965 , vol. 8, p. 715 - 718
反应条件
hydrogen bromide 6 h; Heating;
参考文献
Sikdar, Atul P.; Chetri, Ajoy B.; Das, Pranab J.
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2003 , vol. 42, # 11 p. 2878 - 2881
参考文献
Fischer,E.; Mouneyrat
Chemische Berichte, 1900 , vol. 33, p. 2383
反应条件
hydrogenchloride in 1,4-dioxane; water T=100°C;
参考文献
Pan, Hongjie; Xie, Ying; Liu, Mao; Shi, Yian
RSC Advances, 2014 , vol. 4, # 5 p. 2389 - 2392
反应条件
D-amidase-substance from pseudomonas-cultures T=37°C;
参考文献
Kameda et al.
Nature (London, United Kingdom), 1958 , vol. 181, p. 1225
反应条件
D-glucose; corn steep liquor; fungus Beauveria bassiana ATCC 7159 in ethanol; water Hydrolysis; 72 h; Enzymatic reaction; Title compound not separated from byproducts;
参考文献
Holland, Herbert L.; Andreana, Peter R.; Salehzadeh-Asl, Reza; Van Vliet, Aaron; Ihasz, Nancy J.; Brown, Frances M.
Monatshefte fur Chemie, 2000 , vol. 131, # 6 p. 667 - 672
