DHA 甲酯 Fame 22:6n-3 全顺-4,7,10,13,16,19-二十二碳六烯酸甲酯合成路线 （共 26 条）
反应条件
1: (i) EtMgBr, THF, (ii) CuCN, (iii) /BRN= 1932459/ 2: (i) H2, quinoline, Pd-CaCO3, pentyl acetate, (ii) /BRN= 1098229/, aq. HCl View Scheme
参考文献
Hoppe-Seyler's Zeitschrift fuer physiologische Chemie, , vol. 352, # 4 p. 542 - 548
反应条件
1: (i) EtMgBr, Et2O, (ii) /BRN= 1841586/, CuCl 2: (i) H2, Lindlar catalyst, EtOH, (ii) /BRN= 102415/, MeOH, Et2O View Scheme
参考文献
Recueil des Travaux Chimiques des Pays-Bas, , vol. 82, p. 1015 - 1025
反应条件
(i) H2, Lindlar catalyst, EtOH, (ii) /BRN= 102415/, MeOH, Et2O; Multistep reaction;
参考文献
Recueil des Travaux Chimiques des Pays-Bas, , vol. 82, p. 1015 - 1025
反应条件
T=55°C; 1.5 h; Product distribution / selectivity;
参考文献
WO2008/86495 A1, ;
Page/Page column 18; 20-21; 27 ;
反应条件
1: With lithium aluminium tetrahydride in tetrahydrofuran T=0°C; Inert atmosphere; 2: With water; ammonium chloride in tetrahydrofuran Product distribution / selectivity;
参考文献
PRONOVA BIOPHARMA NORGE AS
Patent: WO2009/134147 A1, 2009 ;
Location in patent: Page/Page column 30 ;
反应条件
lithium hydroxide in tetrahydrofuran; water
参考文献
Sandri; Viala
Journal of Organic Chemistry, 1995 , vol. 60, # 20 p. 6627 - 6630
