2-氯-N,N-二丁基乙酰胺合成路线 （共 13 条）
反应条件
in diethyl ether T=-40 - 20°C;
参考文献
Seguin, Helene; Gardette, Daniel; Moreau, Marie-France; Madelmont, Jean-Claude; Gramain, Jean-Claude
Synthetic Communications, 1998 , vol. 28, # 22 p. 4257 - 4272
反应条件
1: chloroacetic acid With dicyclohexyl-carbodiimide in dichloromethane T=20°C; 0.5 h; 2: dibutylamine With 4-(N,N-dimethlyamino)pyridine in dichloromethane T=20°C;
参考文献
Falco, Jose Luis; Pique, Maria; Gonzalez, Miguel; Buira, Irma; Mendez, Eva; Terencio, Jose; Perez, Cristina; Princep, Marta; Palomer, Albert; Guglietta, Antonio
European Journal of Medicinal Chemistry, 2006 , vol. 41, # 8 p. 985 - 990
参考文献
Eastman Kodak Company
Patent: US4895951 A1, 1990 ;
反应条件
in dichloromethane T=-25 - 20°C; 3.5 h;
参考文献
Nechepurenko; Komarova; Vasil'ev; Salakhutdinov
Chemistry of Natural Compounds, 2013 , vol. 48, # 6 p. 1047 - 1053
Khim. Prir. Soedin., 2012 , vol. 48, # 6 p. 924 - 929,6
参考文献
Svetkin,Yu.V.
J. Gen. Chem. USSR (Engl. Transl.), 1965 , vol. 35, # 5 p. 834 - 836,837 - 839
反应条件
1: 70 percent / 1 h / 200 °C 2: 1.) potassium / 1.) xylene, 115-125 deg C, 1 h, 2.) 120 deg C, 1.5 h View Scheme
参考文献
Medved', T. Ya.; Chmutova, M. K.; Nesterova, N. P.; Koiro, O. E.; Kochetkova, N. E.; et al.
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1981 , vol. 30, # 9 p. 1743 - 1747
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1981 , vol. 30, # 9 p. 2121 - 2127
反应条件
sodium methylate in N-methyl-acetamide; water
参考文献
Occidental Research Corporation
Patent: US4396556 A1, 1983 ;
反应条件
T=115 - 140°C; P=20 - 35 Torr; 1 h;
参考文献
Chauzov, V. A.; Studnev, Yu. N.; Iznoskova, M. G.; Fokin, A. V.
J. Gen. Chem. USSR (Engl. Transl.), 1987 , vol. 57, # 1 p. 110 - 113,93 - 95
反应条件
1: 72 percent / NaH / tetrahydrofuran / 2 h / 20 °C 2: 60 percent / KOH / ethanol / 12 h / 0 °C 3: 35 percent / 0.25 h / 150 °C / 4 Torr 4: 90 percent / LiAlH4 / diethyl ether / 1 h / 0 - 20 °C View Scheme
参考文献
Seguin, Helene; Gardette, Daniel; Moreau, Marie-France; Madelmont, Jean-Claude; Gramain, Jean-Claude
Synthetic Communications, 1998 , vol. 28, # 22 p. 4257 - 4272
反应条件
1: 81 percent / acetonitrile / 18 h / Heating
2: 95 percent / NaOH / H2O
3: 72 percent / benzene / 18 h / Heating
4: 1) triethyloxonium fluoroborate 2) sodium borohydride / 1) methylene dichloride, 25 deg C, 20 hr. 2) ethanol, 0 deg C, 3 hr.
5: benzene / 2 h / Heating
View Scheme
参考文献
Cereda, E.; Bellora, E.; Donetti, A.
Tetrahedron Letters, 1980 , vol. 21, p. 4977 - 4980
