1: formic acid With acetic anhydride T=50 - 60°C; 3 h; Inert atmosphere; 2: ethyl 6-(aminomethyl)-3-pyridinecarboxylate hydrochloride T=20°C; 8 h; Inert atmosphere; 3: With sodium hydrogencarbonate in water

1.1: triethylamine; methanesulfonyl chloride / dichloromethane / 0 °C 1.2: 60 °C 2.1: triphenylphosphine / tetrahydrofuran / 60 °C 3.1: acetic anhydride / 0.5 h / 50 °C 3.2: 20 °C 4.1: trichlorophosphate / toluene / Reflux View Scheme

1.1: calcium chloride; sodium tetrahydroborate / ethanol / 0.75 h / -5 °C 2.1: triethylamine; methanesulfonyl chloride / dichloromethane / 0 °C 2.2: 60 °C 3.1: triphenylphosphine / tetrahydrofuran / 60 °C 4.1: acetic anhydride / 0.5 h / 50 °C 4.2: 20 °C 5.1: trichlorophosphate / toluene / Reflux View Scheme

1.1: triphenylphosphine / tetrahydrofuran / 60 °C 2.1: acetic anhydride / 0.5 h / 50 °C 2.2: 20 °C 3.1: trichlorophosphate / toluene / Reflux View Scheme

1.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 20 °C / |Inert atmosphere 1.2: |Inert atmosphere 2.1: N,N-dimethylcarbamoyl chloride / dichloromethane / 48 h / 20 °C / |Inert atmosphere 3.1: hydrogenchloride; palladium 10 on activated carbon; hydrogen / water; ethanol / 12 h / |Inert atmosphere 4.1: acetic anhydride / 3 h / 50 - 60 °C / |Inert atmosphere 4.2: 8 h / 20 °C / |Inert atmosphere View Scheme

1.1: N,N-dimethylcarbamoyl chloride / dichloromethane / 48 h / 20 °C / |Inert atmosphere 2.1: hydrogenchloride; palladium 10 on activated carbon; hydrogen / water; ethanol / 12 h / |Inert atmosphere 3.1: acetic anhydride / 3 h / 50 - 60 °C / |Inert atmosphere 3.2: 8 h / 20 °C / |Inert atmosphere View Scheme

1.1: hydrogenchloride; palladium 10 on activated carbon; hydrogen / water; ethanol / 12 h / |Inert atmosphere 2.1: acetic anhydride / 3 h / 50 - 60 °C / |Inert atmosphere 2.2: 8 h / 20 °C / |Inert atmosphere View Scheme