4-氰基-4-(4-氟苯基)哌啶-1-羧酸叔丁酯合成路线 （共 6 条）
反应条件
1: 2-(4-fluorophenyl)-acetonitrile With sodium hydride in dimethyl sulfoxide T=20°C; 1.5 h; 2: N-(2,2'-bischloro)diethyl-N-(1,1-dimethylethoxy)carbonyl amine in dimethyl sulfoxide T=20°C; 2 h;
参考文献
SCHERING CORPORATION
Patent: WO2004/4722 A1, 2004 ;
Location in patent: Page/Page column 20; 50-51 ;
WO 2004/004722 A1
反应条件
N-ethyl-N,N-diisopropylamine in tetrahydrofuran T=20°C; 24 h;
参考文献
ASTRAZENECA AB
Patent: WO2004/56771 A1, 2004 ;
Location in patent: Page 23 ;
WO 2004/056771 A1
反应条件
1: 4-(4-fluorophenyl)-1-methylpiperidine-4-carbonitrile With 1-chloroethyl chlorocarbonate in 1,2-dichloro-ethane T=85°C; 2: di-tert-butyl dicarbonate With sodium hydroxide in methanol
参考文献
Liu, Jian; Jian, Tianying; Sebhat, Iyassu; Nargund, Ravi
Tetrahedron Letters, 2006 , vol. 47, # 29 p. 5115 - 5117
反应条件
1.1: Bu4N(1+)*HSO4(1-) / aq. NaOH 2.1: 1-chloroethylchloroformate / 1,2-dichloro-ethane / 85 °C 2.2: aq. NaOH / methanol View Scheme
参考文献
Liu, Jian; Jian, Tianying; Sebhat, Iyassu; Nargund, Ravi
Tetrahedron Letters, 2006 , vol. 47, # 29 p. 5115 - 5117
反应条件
1.1: Bu4N(1+)*HSO4(1-) / aq. NaOH 2.1: 1-chloroethylchloroformate / 1,2-dichloro-ethane / 85 °C 2.2: aq. NaOH / methanol View Scheme
参考文献
Liu, Jian; Jian, Tianying; Sebhat, Iyassu; Nargund, Ravi
Tetrahedron Letters, 2006 , vol. 47, # 29 p. 5115 - 5117
反应条件
ammonia; hydrogen; nickel in ethanol
T=20°C; P=2585.81 Torr; 24 h;
参考文献
ASTRAZENECA AB
Patent: WO2004/56771 A1, 2004 ;
Location in patent: Page 23 ;
WO 2004/056771 A1
