1,2-二甲氧基-4-甲硫基苯合成路线 （共 5 条）
反应条件
1: N-methyl-N-formyl-aniline With trichlorophosphate
T=40 - 50°C; Vilsmeier reaction;
2: 1,4-dimethoxy-2-methylthiobenzene T=70°C; 0.25 h;
参考文献
Gallardo-Godoy, Alejandra; Fierro, Angelica; McLean, Thomas H.; Castillo, Mariano; Cassels, Bruce K.; Reyes-Parada, Miguel; Nichols, David E.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 7 p. 2407 - 2419
反应条件
(i) SnCl4, CH2Cl2, (ii) H2O; Multistep reaction;
参考文献
Nichols; Shulgin
Journal of Pharmaceutical Sciences, 1976 , vol. 65, # 10 p. 1554 - 1556
反应条件
1.1: POCl3 / 40 - 50 °C
1.2: 73 percent / 0.25 h / 70 °C
2.1: 73 percent / NH4OAc / Heating
View Scheme
参考文献
Nichols; Shulgin
Journal of Pharmaceutical Sciences, 1976 , vol. 65, # 10 p. 1554 - 1556
反应条件
1: (i) SnCl4, CH2Cl2, (ii) H2O
2: NH4OAc
View Scheme
参考文献
Nichols; Shulgin
Journal of Pharmaceutical Sciences, 1976 , vol. 65, # 10 p. 1554 - 1556
反应条件
1: (i) SnCl4, CH2Cl2, (ii) H2O
2: NH4OAc
3: LiAlH4 / tetrahydrofuran
View Scheme
参考文献
Nichols; Shulgin
Journal of Pharmaceutical Sciences, 1976 , vol. 65, # 10 p. 1554 - 1556
