2-甲基-6-氧代庚酸甲酯合成路线 （共 15 条）
反应条件
sulfuric acid
T=65°C; 5 h;
参考文献
SUMITOMO CHEMICAL COMPANY, LIMITED
Patent: US2009/118534 A1, 2009 ;
Location in patent: Page/Page column 8 ;
反应条件
hydrogen; palladium on activated charcoal in methanol; acetone
T=20°C; Hydrogenation; P=2327.17 Torr; 15 h;
参考文献
Wenkert, Ernest; Khatuya, Haripada
Synthetic Communications, 1999 , vol. 29, # 17 p. 3051 - 3055
反应条件
cerium(IV) sulphate; oxygen
T=50°C; Oxidation; 6 h;
参考文献
He, Liangyou; Horiuchi, C. Akira
Bulletin of the Chemical Society of Japan, 1999 , vol. 72, # 11 p. 2515 - 2521
反应条件
1: 1.) EtONa / 1.) EtOH, reflux, 5 min, 2.) ethanol, reflux, 18 h
2: aq. KOH / ethanol / 4 h / Heating
3: H2SO4 / H2O
4: 1 h / 160 °C
5: conc. H2SO4 / 4 h / Heating
View Scheme
参考文献
Wani, Mansukh C.; Vishnuvajjala, B. Rao; Swain, William E.; Rector, Douglas H.; Cook, Clarence E.; et al.
Journal of Medicinal Chemistry, 1983 , vol. 26, # 3 p. 426 - 430
反应条件
1: SOCl2, C5H5N2Na / diethyl ether
2: 1.) Triphenylphosphine, Br2 / 1.) CH2Cl2, 15 min., 2.) pyridine, ambient. temp., 1 h
4: Hg(OAc)2, Jones' reagent / acetone; H2O / 6 h / 20 °C
5: 83 percent
View Scheme
参考文献
Joshi, N..N.; Mamdapur, V. R.; Chadha, M. S.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1984 , vol. 23, # 3 p. 238 - 240
反应条件
1: 1.) Triphenylphosphine, Br2 / 1.) CH2Cl2, 15 min., 2.) pyridine, ambient. temp., 1 h
3: Hg(OAc)2, Jones' reagent / acetone; H2O / 6 h / 20 °C
4: 83 percent
View Scheme
参考文献
Joshi, N..N.; Mamdapur, V. R.; Chadha, M. S.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1984 , vol. 23, # 3 p. 238 - 240
反应条件
1: 71 percent / ethanol / 0.5 h / Ambient temperature
2: 1.) NaOH, 2.) H2SO4 / 1.) Ethanol, reflux, 3 h, 2) reflux
3: Hg(OAc)2, Jones' reagent / acetone; H2O / 6 h / 20 °C
4: 83 percent
View Scheme
参考文献
Joshi, N..N.; Mamdapur, V. R.; Chadha, M. S.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1984 , vol. 23, # 3 p. 238 - 240
反应条件
1: 1.) NaOH, 2.) H2SO4 / 1.) Ethanol, reflux, 3 h, 2) reflux
2: Hg(OAc)2, Jones' reagent / acetone; H2O / 6 h / 20 °C
3: 83 percent
View Scheme
参考文献
Joshi, N..N.; Mamdapur, V. R.; Chadha, M. S.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1984 , vol. 23, # 3 p. 238 - 240
反应条件
2: Hg(OAc)2, Jones' reagent / acetone; H2O / 6 h / 20 °C
3: 83 percent
View Scheme
参考文献
Joshi, N..N.; Mamdapur, V. R.; Chadha, M. S.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1984 , vol. 23, # 3 p. 238 - 240
反应条件
1: 3N HCl
View Scheme
参考文献
Fujisawa, Tamotsu; Sato, Toshio; Kawara, Tatsuo; Noda, Atsunari
Tetrahedron Letters, 1982 , vol. 23, # 31 p. 3193 - 3194
