2,4,6-三甲基苯甲腈合成路线 （共 81 条）
反应条件
1: fuming nitric acid 2: concentrated hydrochloric acid / 180 - 200 °C View Scheme
参考文献
Kuester; Stallberg
Justus Liebigs Annalen der Chemie, 1894 , vol. 278, p. 222
反应条件
ethanol; nickel T=150°C; P=110326 Torr;
参考文献
Fuson; Denton
Journal of the American Chemical Society, 1941 , vol. 63, p. 654
反应条件
[RhCl(η2:η2-cycloocta-1,5-diene)]2; methyl-ethyl phosphite; tri-iso-propylsilane in 2-cyclohexylethanol T=160°C; 15 h; Inert atmosphere;
参考文献
Tobisu, Mamoru; Nakamura, Ryo; Kita, Yusuke; Chatani, Naoto
Bulletin of the Korean Chemical Society, 2010 , vol. 31, # 3 p. 582 - 587
反应条件
trifluorormethanesulfonic acid in nitromethane T=100°C; 6 h; Yield given;
参考文献
El-Khagawa, Ahmed M.
Bulletin de la Societe Chimique de France, 1987 , # 2 p. 372 - 374
反应条件
1: 47 percent / CeCl3 / tetrahydrofuran / 16 h / Heating 2: 88 percent / Na; EtOH; liq. NH3 / tetrahydrofuran / 1 h / Heating 3: 37 percent / CH2Cl2 / 40 h / 20 °C 4: 72 percent / DIBAL / tetrahydrofuran / 40 h / 20 °C 5: 90 percent / aq. HCl / methanol / 6 h / Heating View Scheme
参考文献
Kohara, Takehiro; Hashimoto, Yukihiko; Shioya, Rieko; Saigo, Kazuhiko
Tetrahedron Asymmetry, 1999 , vol. 10, # 24 p. 4831 - 4840
反应条件
oxygen in gas enthalpy of reaction; Thermodynamic data;
参考文献
Acree, W. E.; Tucker, Sheryl A.; Zvaigzne, Anita I.; Meng-Yan, Yang; Pilcher, G.; Ribeiro da Silva, Maria D. M. C.
Journal of Chemical Thermodynamics, 1991 , vol. 23, # 1 p. 31 - 36
反应条件
cerium(III) chloride in tetrahydrofuran T=-50°C; 1.) 1 h, 2.) 3 h;
参考文献
Timberlake, Jack W.; Pan, Dawei; Murray, Jane; Jursic, Branko S.; Chen, Tonghua
Journal of Organic Chemistry, 1995 , vol. 60, # 16 p. 5295 - 5298
反应条件
1: CeCl3 / tetrahydrofuran / -50 °C / 1.) 1 h, 2.) 3 h
2: 1.) CeCl3 / 1.) THF, 0 deg C, 2 h, 2.) THF, 0 deg C, 1 h
View Scheme
参考文献
Timberlake, Jack W.; Pan, Dawei; Murray, Jane; Jursic, Branko S.; Chen, Tonghua
Journal of Organic Chemistry, 1995 , vol. 60, # 16 p. 5295 - 5298
反应条件
1.1: BuLi / hexane; diethyl ether / Heating
1.2: diethyl ether / Heating
2.1: sodium acetate; N2O4 / CCl4 / 0 °C
3.1: LiAlH4 / diethyl ether / -50 - -10 °C
View Scheme
参考文献
Hu, Yingmo; Ishikawa, Yui; Hirai, Katsuyuki; Tomioka, Hideo
Bulletin of the Chemical Society of Japan, 2001 , vol. 74, # 11 p. 2207 - 2218
反应条件
sulfuric acid; acetic acid
T=90°C; 7 h;
参考文献
Moorthy, Jarugu Narasimha; Singhal, Nidhi
Journal of Organic Chemistry, 2005 , vol. 70, # 5 p. 1926 - 1929
