2-(1H-吡唑-1-基)苯甲腈合成路线 （共 9 条）
反应条件
potassium hydroxide; 18-crown-6 ether in DMF (N,N-dimethyl-formamide) T=20°C;
参考文献
GRAFFINITY PHARMACEUTICALS AG
Patent: WO2005/95343 A1, 2005 ;
Location in patent: Page/Page column 53-54 ;
WO 2005/095343 A1
反应条件
palladium diacetate; copper(ll) bromide in N,N-dimethyl-formamide T=130°C; 48 h;
参考文献
Jia, Xiaofei; Yang, Dongpeng; Wang, Wenhui; Luo, Fang; Cheng, Jiang
Journal of Organic Chemistry, 2009 , vol. 74, # 24 p. 9470 - 9474
反应条件
1: 1-(o-aminophenyl)-pyrazole With hydrogenchloride; sodium nitrite in water T=0 - 5°C; 2: copper (I) cyanide; potassium cyanide in water T=60°C; 0.333333 h;
参考文献
De La Hoz, Antonio; Diaz-Ortiz, Angel; Elguero, Jose; Martinez, Luis J.; Moreno, Andres; Sanchez-Migallon, Ana
Tetrahedron, 2001 , vol. 57, # 20 p. 4397 - 4403
反应条件
copper(I) bromide in N,N-dimethyl-formamide T=130°C; 18 h;
参考文献
Jin, Jisong; Wen, Qiaodong; Lu, Ping; Wang, Yanguang
Chemical Communications, 2012 , vol. 48, # 79 p. 9933 - 9935
反应条件
1.1: 93 percent / hydrazine hydrate / Pd/C / ethanol / 1 h / Heating 2.1: NaNO2; HCl / H2O / 0 - 5 °C 2.2: 63 percent / CuCN / H2O / 0.33 h / 60 °C View Scheme
参考文献
De La Hoz, Antonio; Diaz-Ortiz, Angel; Elguero, Jose; Martinez, Luis J.; Moreno, Andres; Sanchez-Migallon, Ana
Tetrahedron, 2001 , vol. 57, # 20 p. 4397 - 4403
反应条件
1.1: 77 percent / H2SO4 / ethanol / 4 h / Heating 2.1: 93 percent / hydrazine hydrate / Pd/C / ethanol / 1 h / Heating 3.1: NaNO2; HCl / H2O / 0 - 5 °C 3.2: 63 percent / CuCN / H2O / 0.33 h / 60 °C View Scheme
参考文献
De La Hoz, Antonio; Diaz-Ortiz, Angel; Elguero, Jose; Martinez, Luis J.; Moreno, Andres; Sanchez-Migallon, Ana
Tetrahedron, 2001 , vol. 57, # 20 p. 4397 - 4403
反应条件
[Rh(pentamethylcyclopentadienyl)(MeCN)3](SbF6)2; silver carbonate in 1,4-dioxane T=120°C; 24 h; Schlenk techniqueInert atmosphere;
参考文献
Gong, Tian-Jun; Xiao, Bin; Cheng, Wan-Min; Su, Wei; Xu, Jun; Liu, Zhao-Jing; Liu, Lei; Fu, Yao
Journal of the American Chemical Society, 2013 , vol. 135, # 29 p. 10630 - 10633
反应条件
lithium aluminium tetrahydride in tetrahydrofuran 1 h;
参考文献
Gong, Tian-Jun; Xiao, Bin; Cheng, Wan-Min; Su, Wei; Xu, Jun; Liu, Zhao-Jing; Liu, Lei; Fu, Yao
Journal of the American Chemical Society, 2013 , vol. 135, # 29 p. 10630 - 10633
反应条件
hydrogenchloride in water Heating / reflux;
参考文献
Neurogen Corporation
Patent: US6723743 B1, 2004 ;
Location in patent: Page/Page column 142 ;
US 6723743 B1
