(4-氯苯基硫)丙-2-酮合成路线 （共 14 条）
反应条件
aluminium trichloride 1.) benzene, 0 deg C, 0.5 h, 2.) reflux, 3 h;
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 677 - 685
反应条件
1: (4-chlorophenyl)thiomethyl methyl ketone With thionyl chloride in dichloromethane
T=-78°C; 0.5 h;
2: 2-chloro-5-aminobenzonitrile With N,N,N',N'-tetra-methylnaphthalene-1,8-diamine in dichloromethane
T=-78°C; 2.5 h;
3: With triethylamine in dichloromethane
T=-78 - 20°C;
参考文献
ASTRAZENECA AB
Patent: WO2003/101961 A1, 2003 ;
Location in patent: Page 19-20 ;
WO 03/101961 A1
反应条件
1: 3-nitro-aniline With tert-butylhypochlorite in tetrahydrofuran
T=-78 - -65°C; 0.416667 h;
2: (4-chlorophenyl)thiomethyl methyl ketone in tetrahydrofuran
T=-65°C; 2 h;
3: With triethylamine in tetrahydrofuran
T=-65 - 20°C;
参考文献
ASTRAZENECA AB
Patent: WO2003/101961 A1, 2003 ;
Location in patent: Page 43 ;
WO 03/101961 A1
反应条件
1: 3-nitro-aniline With tert-butylhypochlorite in tetrahydrofuran
T=-78 - -65°C; 0.416667 h;
2: (4-chlorophenyl)thiomethyl methyl ketone in tetrahydrofuran
T=-78 - -65°C; 2 h;
3: With hydrogenchloride; triethylamine
more than 3 stages;
参考文献
ASTRAZENECA AB
Patent: WO2004/106302 A1, 2004 ;
Location in patent: Page 25 ;
WO 2004/106302 A1
