5-氨基-1-苯并噻吩-2-羧酸乙酯合成路线 （共 10 条）
反应条件
hydrogenchloride; iron in ethanol; water Reduction; 1 h; Heating;
参考文献
Osuga, Hideji; Suzuki, Hitomi; Tanaka, Kazuhiko
Bulletin of the Chemical Society of Japan, 1997 , vol. 70, # 4 p. 891 - 897
反应条件
hydrazine hydrate in ethanol
反应条件
1: 88 percent / K2CO3 / dimethylformamide / 0 - 20 °C 2: 96 percent / iron; HCl / ethanol; H2O / 1 h / Heating View Scheme
参考文献
Bulletin of the Chemical Society of Japan, , vol. 70, # 4 p. 891 - 897
反应条件
1: ethyl 5-amino-1-benzothiophene-2-carboxylate With hydrogenchloride; sodium nitrite in tetrahydrofuran T=2 - 3°C; Diazotization; 0.333333 h; 2: copper (I) cyanide With potassium cyanide T=3 - 50°C; Sandmeyer reaction; 3.5 h;
参考文献
Ono, Shin'ichiro; Yoshida, Tomohiro; Maeda, Kazuhiro; Kosaka, Keigo; Inoue, Yoshihisa; Imada, Teruaki; Fukaya, Chikara; Nakamura, Norifumi
Chemical and Pharmaceutical Bulletin, 1999 , vol. 47, # 12 p. 1694 - 1712
反应条件
1: 91 percent / bromine, anhydreous sodium acetate / acetic acid / roomtemp., 1 h, then 15 min heating 3: 95 percent / 50percent sulphuric acid / acetic acid / reflux, 8h, then room temp. 4: 1) thionylchloride, 2) conc. ammonia / 1) benzene, reflux, 2) ether, 30 min View Scheme
参考文献
Sharma, K. S.; Lata, Suman
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1984 , vol. 23, # 1 p. 38 - 41
反应条件
1: 91 percent / bromine, anhydreous sodium acetate / acetic acid / roomtemp., 1 h, then 15 min heating 3: 96 percent / LAH / diethyl ether / 2 h / Heating View Scheme
参考文献
Sharma, K. S.; Lata, Suman
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1984 , vol. 23, # 1 p. 38 - 41
反应条件
1: 91 percent / bromine, anhydreous sodium acetate / acetic acid / roomtemp., 1 h, then 15 min heating 3: 95 percent / 50percent sulphuric acid / acetic acid / reflux, 8h, then room temp. 4: thionylchloride / benzene / Heating View Scheme
参考文献
Sharma, K. S.; Lata, Suman
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1984 , vol. 23, # 1 p. 38 - 41
反应条件
1: 91 percent / bromine, anhydreous sodium acetate / acetic acid / roomtemp., 1 h, then 15 min heating 3: 95 percent / 50percent sulphuric acid / acetic acid / reflux, 8h, then room temp. View Scheme
参考文献
Sharma, K. S.; Lata, Suman
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1984 , vol. 23, # 1 p. 38 - 41
反应条件
bromine; sodium acetate in acetic acid
roomtemp., 1 h, then 15 min heating;
参考文献
Sharma, K. S.; Lata, Suman
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1984 , vol. 23, # 1 p. 38 - 41
反应条件
(i) Na, EtOH, (ii) /BRN= 172959/, NaNO2, HCl, (iii) BF3-Et2O; Multistep reaction;
参考文献
Sharma,K.S.; Singh,V.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1976 , vol. 14, p. 797 - 798
