1.1: 81 percent / KOH; H2O / methanol / 2 h / Heating 2.1: Cl2ZrCp2 / 1,2-dichloro-ethane / 8 h / 23 °C 2.2: 88 percent / I2 / tetrahydrofuran; 1,2-dichloro-ethane / 0.25 h / 0 °C 3.1: t-BuLi / diethyl ether; pentane / -78 °C 3.2: ZnBr2 / diethyl ether; tetrahydrofuran / -78 - 0 °C 3.3: Cl2Pd(dppf)(CH2Cl2) / tetrahydrofuran; diethyl ether; pentane / 23 °C 4.1: 84 percent / KOH / methanol; H2O / Heating 5.1: Cl2ZrCp2 / 1,2-dichloro-ethane / 1 h / 23 °C 5.2: 90 percent / Cl2Ni(PPh)2; n-BuLi; PPh3 / tetrahydrofuran / 1 h / 23 °C View Scheme