(3-羟基-3-苯基丙基)氨基甲酸叔丁酯合成路线 （共 12 条）
反应条件
1: 3-Oxo-3-phenylpropanenitrile With lithium aluminium tetrahydride in tetrahydrofuran T=60°C; 2.25 h; Cooling with ice; 2: With water; sodium hydroxide in tetrahydrofuran T=20°C; 0.333333 h; Cooling with ice; 3: di-tert-butyl dicarbonate in tetrahydrofuran
参考文献
US2012/184548 A1, ;
Page/Page column 12; 13 ;
US 20120184548 A1
反应条件
in tetrahydrofuran 0.5 h;
参考文献
WO2006/113837 A2, ;
Page/Page column 122 ;
WO 2006/113837 A2
反应条件
sodium tetrahydroborate in ethanol T=0 - 23°C; 3 h;
参考文献
Advanced Synthesis and Catalysis, , vol. 346, # 2-3 p. 185 - 189
反应条件
triethylamine in tetrahydrofuran
反应条件
1: lithium aluminium tetrahydride; sodium hydroxide / tetrahydrofuran 2: triethylamine / tetrahydrofuran View Scheme
参考文献
US2012/184508 A1, ;
US 20120184508 A1
US2012/184542 A1, ;
US 20120184542 A1
US2012/184548 A1, ;
US 20120184548 A1
US2012/184562 A1, ;
US 20120184562 A1
US2012/238564 A1, ;
US 20120238564 A1
反应条件
1: LiAlH4 / tetrahydrofuran / 5 h / Heating 2: 41 percent / Et3N / CH2Cl2 / 2 h / 23 °C View Scheme
参考文献
Advanced Synthesis and Catalysis, , vol. 346, # 2-3 p. 185 - 189
反应条件
1: (-)-sparteine; O2; Molecular sieves 3A / Pd(nbd)Cl2 / toluene / 24 h / 80 °C / 760.05 Torr 2: 78 percent / LiAlH4 / tetrahydrofuran / 5.5 h / Heating View Scheme
参考文献
Caspi, Daniel D.; Ebner, David C.; Bagdanoff, Jeffrey T.; Stoltz, Brian M.
Advanced Synthesis and Catalysis, 2004 , vol. 346, # 2-3 p. 185 - 189
反应条件
3 A molecular sieve; oxygen; (-)-sparteine; PdCl2(nbd) in toluene T=80°C; P=760.051 Torr; 24 h; Title compound not separated from byproducts.;
参考文献
Caspi, Daniel D.; Ebner, David C.; Bagdanoff, Jeffrey T.; Stoltz, Brian M.
Advanced Synthesis and Catalysis, 2004 , vol. 346, # 2-3 p. 185 - 189
反应条件
dipyridinium dichromate in N,N-dimethyl-formamide T=23°C; 10 h;
参考文献
Caspi, Daniel D.; Ebner, David C.; Bagdanoff, Jeffrey T.; Stoltz, Brian M.
Advanced Synthesis and Catalysis, 2004 , vol. 346, # 2-3 p. 185 - 189
反应条件
oxygen; (-)-sparteine in toluene T=80°C; P=760.051 Torr; 24 h; Molecular sieve; optical yield given as percent ee;
参考文献
Ebner, David C.; Bagdanoff, Jeffrey T.; Ferreira, Eric M.; McFadden, Ryan M.; Caspi, Daniel D.; Trend, Raissa M.; Stoltz, Brian M.
Chemistry - A European Journal, 2009 , vol. 15, # 47 p. 12978 - 12992
