1,2,3,6-四氢-1-[(1R)-1-苯基乙基]-4-[4-(苯基甲氧基)苯基]吡啶合成路线 （共 6 条）
反应条件
formaldehyd; conc. sulphuric acid in 1,4-dioxane; hexane; dichloromethane; water; isopropyl alcohol
参考文献
Hoffman-La Roche Inc.
Patent: US6268499 B1, 2001 ;
反应条件
formaldehyd; conc. sulphuric acid in 1,4-dioxane; hexane; dichloromethane; water; isopropyl alcohol
参考文献
Hoffmann-La Roche Inc.
Patent: US6274735 B1, 2001 ;
反应条件
formaldehyd; conc. sulphuric acid in 1,4-dioxane; dichloromethane; water; isopropyl alcohol
参考文献
Hoffman-La Roche Inc.
Patent: US6268499 B1, 2001 ;
反应条件
sodium hydroxide in methanol; anhydrous dichloroethane; dichloromethane; water; ethyl acetate
参考文献
Hoffman-La Roche Inc.
Patent: US6268499 B1, 2001 ;
反应条件
1: With hydrogenchloride in 1,4-dioxane T=40 - 74°C; 20 h; 2: With sulfuric acid in 1,4-dioxane T=100°C; 7 h;
参考文献
Maerki, H. P.; Binggeli, A.; Bittner, B.; Bohner-Lang, V.; Breu, V.; Bur, D.; Coassolo, Ph.; Clozel, J. P.; D'Arcy, A.; Doebeli, H.; Fischli, W.; et al.
Farmaco, 2001 , vol. 56, # 1-2 p. 21 - 28
反应条件
1.1: BH3*THF / tetrahydrofuran / 1 h / 20 °C
1.2: 50 percent / aq. NaOH; H2O2 / tetrahydrofuran / 3 h / 45 °C
2.1: H2 / Pd/C / methanol / 15 h / 20 °C
3.1: Et3N / methanol / 3 h / -10 - 0 °C
View Scheme
参考文献
Maerki, H. P.; Binggeli, A.; Bittner, B.; Bohner-Lang, V.; Breu, V.; Bur, D.; Coassolo, Ph.; Clozel, J. P.; D'Arcy, A.; Doebeli, H.; Fischli, W.; et al.
Farmaco, 2001 , vol. 56, # 1-2 p. 21 - 28
